2. Membrane Transporter/Ion Channel NF-κB
  3. Na+/K+ ATPase NF-κB
  4. 4-PSQ

4-PSQ 是一种具有口服活性的神经保护剂。4-PSQ 兼具抗氧化、抗炎活性。4-PSQ 能通过调控 Na⁺，K⁺-ATP 酶活性、NFκB 信号通路及 p21 表达，改善小鼠的认知障碍与抑郁、焦虑样情绪异常。4-PSQ 可用于神经系统疾病的研究。

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4-PSQ

4-PSQ Chemical Structure

CAS No. : 1415931-33-7

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4-PSQ 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

4-PSQ is an orally active neuroprotective agent. 4-PSQ possesses both antioxidant and anti-inflammatory activities. 4-PSQ improves cognitive impairment and depressive- and anxiety-like emotional abnormalities in mice by regulating the activity of Na+, K+-ATPase, the NFκB signaling pathway, and the expression of p21. 4-PSQ can be used for the research of neurological diseases[1].

体内研究
(In Vivo)

4-PSQ (1 mg/kg；口服；每日；10 天) 可逆转 Vincristine (HY-N0488A) 诱导的小鼠认知、抑郁样及焦虑样行为损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss mice with Vincristine (VCR)-induced neurotoxicity (male and female, 60 days old)[1]
Dosage: 1 mg/kg
Administration: p.o.; daily; days 7 to 16
Result: Restored short-term and long-term memory impairments induced by vincristine in both sexes.
Normalized depressive-like behavior in both sexes.
Reversed anxiety-like behavior in both sexes.
Counteracted vincristine-induced inhibition of Na+,K+-ATPase activity in the cerebral cortex, spinal cord, and cerebellum of male mice, and in the cerebellum of female mice.
Normalized vincristine-induced increased p21 mRNA expression in the cerebral cortex of female mice.
Normalized vincristine-induced increased NFκB mRNA expression in the cerebral cortex of male mice, and in the spinal cord of male and female mice.
分子量

318.66

Formula

C15H10ClNSe
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

4-PSQ 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-PSQ1415931-33-7Na+/K+ ATPaseNF-κBSodium potassium pumpNuclear factor-κBNuclear factor-kappaBanxiety-like behaviorSwiss miceglutamatergic pathwaysvincristinenitrergic pathwayscognitive impairmentdepressive-like behaviorInhibitorinhibitorinhibit

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目录号：
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