2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. 4SC-207

4SC-207 是一种强效的、口服有效的微管 (microtubule) 抑制剂。4SC-207 通过抑制微管生长来抑制体外和体内肿瘤细胞的增殖，并促进有丝分裂延迟/阻滞，随后诱导细胞凋亡 (apoptosis) 或异常分裂。4SC-207 可抑制紫杉烷类耐药异种移植小鼠模型中的肿瘤生长。4SC-207 可用于癌症研究，例如结肠腺癌和其他恶性肿瘤。

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4SC-207

4SC-207 Chemical Structure

CAS No. : 871015-11-1

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4SC-207 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

4SC-207 is a potent, orally active microtubule inhibitor. 4SC-207 inhibits microtubule growth to inhibit tumor cell proliferation in vitro and in vivo, and promotes a mitotic delay/arrest, followed by apoptosis or aberrant divisions. 4SC-207 inhibits tumor growth in taxane resistant xenograft mouse models. 4SC-207 can be used for cancer research, such as colon adenocarcinoma and other malignancies[1].

体外研究
(In Vitro)

4SC-207 (10 nM-100 μM，24-72 小时) 降低细胞活力，并仅在增殖的 RKO 细胞中诱导 G2/M 期阻滞[1]。
4SC-207 (10 nM-100 nM，9 小时) 以剂量依赖的方式诱导 HeLa 野生型细胞出现异常分裂、延长有丝分裂或有丝分裂阻滞，并在 100 nM 浓度下影响所有细胞[1]。
4SC-207 (0-2 μM，0-20 分钟) 在体外实验中以剂量依赖的方式抑制纯化的猪脑微管蛋白的聚合[1]。
4SC-207 (50-100 nM) 降低活体 HeLa 细胞中微管的生长速度[1]。
4SC-207 (72 小时) 是一种强效抗增殖剂，对多种肿瘤细胞具有活性，平均 GI50 为 11nM，并且对 HCT-15 和 ACHN 等多药耐药细胞系具有活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

4SC-207 相关抗体:

Cell Viability Assay[1]

Cell Line: RKO cells
Concentration: 10 nM-100 μM
Incubation Time: 72 h
Result: Reduced the percentage of viable cells from 100% to 20% when added at or above a concentration of 100 nM.

Cell Cycle Analysis[1]

Cell Line: RKO cells
Concentration: 100 nM
Incubation Time: 24 h
Result: Showed a strong increase in the percentage of cells in G2/M phase (52% compared to 24% of DMSO-treated cells).
Decreased the amount of cells in G1 and S phases (respectively 14% and 10% compared to 53% and 20% in control cells).
体内研究
(In Vivo)

4SC-207 (60 和 120 mg/kg，灌胃，每周 3 次，持续 3 周) 在 Taxol (HY-B0015) 耐药的 HCT-15 异种移植小鼠模型中表现出抗增殖活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female SCID mice subcutaneously implanted with HCT-15 colon cancer cells[1]
Dosage: 60 and 120 mg/kg
Administration: i.g., 3 times weekly for 3 weeks
Result: Resulted in a reduction in tumor growth, in a dose dependent manner, without evidence of toxicity based on body weight measurements.
Resulted in significant tumor reduction at day 12, day 14, and day 19 at 120 mg/kg.
分子量

382.44

Formula

C19H18N4O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

4SC-207 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4SC-207871015-11-1Microtubule/TubulinApoptosisHCT-15ACHNmicrotubuletaxane resistantcolon adenocarcinomamalignanciesInhibitorinhibitorinhibit

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