2. Anti-infection Apoptosis Metabolic Enzyme/Protease NF-κB MAPK/ERK Pathway Immunology/Inflammation
  3. Influenza Virus Ferroptosis Apoptosis Glutathione Peroxidase NF-κB p38 MAPK Interleukin Related
  4. 5-Hydroxy-6,7-dimethoxyflavone

5-Hydroxy-6,7-dimethoxyflavone 是一种口服有效的铁死亡 (Ferroptosis) 抑制剂。5-Hydroxy-6,7-dimethoxyflavone 通过上调 SLC7A11 和 GPX4 的表达来抑制 H1N1 病毒诱导的铁死亡。5-Hydroxy-6,7-dimethoxyflavone 通过抑制 NF-κB 和 p38 MAPK 信号通路的激活，来减轻炎症反应和抑制细胞凋亡 (apoptosis)。5-Hydroxy-6,7-dimethoxyflavone 可用于 H1N1 流感病毒感染的相关研究。

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5-Hydroxy-6,7-dimethoxyflavone

5-Hydroxy-6,7-dimethoxyflavone Chemical Structure

CAS No. : 2035-05-4

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5-Hydroxy-6,7-dimethoxyflavone 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

5-Hydroxy-6,7-dimethoxyflavone is an orally active inhibitor of ferroptosis (Ferroptosis). 5-Hydroxy-6,7-dimethoxyflavone inhibits H1N1 virus-induced ferroptosis by upregulating the expression of SLC7A11 and GPX4. 5-Hydroxy-6,7-dimethoxyflavone alleviates inflammatory responses and inhibits apoptosis by suppressing the activation of the NF-κB and p38 MAPK signaling pathways. 5-Hydroxy-6,7-dimethoxyflavone can be used in studies related to H1N1 influenza virus infection[1].

体外研究
(In Vitro)

5-Hydroxy-6,7-dimethoxyflavone (25-75 μg/mL; 24 h) 可抑制 H1N1 诱导的 p38 MAPK 和 NF-κB 信号通路激活，并降低 A549 细胞中 IL-8 的表达[1]。
5-Hydroxy-6,7-dimethoxyflavone (25-75 μg/mL; 24 h) 抑制 H1N1 诱导的 A549 细胞凋亡和铁死亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

5-Hydroxy-6,7-dimethoxyflavone 相关抗体:
体内研究
(In Vivo)

5-Hydroxy-6,7-dimethoxyflavone (30-60 mg/kg; p.o.; 每日一次共 7 天) 可改善 H1N1 流感病毒感染小鼠的体重、降低肺指数并减轻肺组织损伤，展现出针对流感诱导性肺损伤的保护活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (female, 6 weeks old, 20 g, infected with H1N1 virus via nasal instillation)[1]
Dosage: 30 mg/kg; 60 mg/kg
Administration: p.o.; once daily; 7 days
Result: Increased mouse body weight.
Reduced lung index.
Alleviated histopathological lung damage including alveolitis, lung vasculitis, peribronchiolar inflammation, and bronchiolar epithelial sloughing.
分子量

298.29

Formula

C17H14O5
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

5-Hydroxy-6,7-dimethoxyflavone 相关分类

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Keywords:

5-Hydroxy-6,7-dimethoxyflavone2035-05-4Influenza VirusFerroptosisApoptosisGlutathione PeroxidaseNF-κBp38 MAPKInterleukin RelatedNuclear factor-κBNuclear factor-kappaBILNF-κB p65ferroptosisGPX4cleaved PARPH1N1 influenza viruscleaved caspase3SLC7A11TRAILIL-8Inhibitorinhibitorinhibit

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