2. Autophagy
  3. Autophagy
  4. 501A054

501A054 是一种自噬 (Autophagy) 激活剂。501A054 可通过自噬激活诱导自噬依赖性细胞死亡。501A054 可用于宫颈癌等自噬调控的研究。

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501A054

501A054 Chemical Structure

CAS No. : 3080980-06-6

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501A054 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

501A054 is an autophagy activator. 501A054 induces autophagy-dependent cell death via autophagy activation. 501A054 can be used in studies on autophagy regulation such as cervical cancer[1].

体外研究
(In Vitro)

501A054 (Compound 3o) (4 h) 可在稳定表达 eGFP-LC3 的 HeLa 细胞中强效激活自噬，EC50 为 2.3 μM[1]。
501A054 (16-32 μM; 4-24 h) 可在 16 μM 作用 4 h 后诱导 eGFP-LC3 HeLa 细胞发生自噬依赖性核周空泡形成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

501A054 相关抗体:

Immunofluorescence[1]

Cell Line: eGFP-LC3 HeLa cells, ATG9A KO HeLa cells
Concentration: 16 μM (eGFP-LC3 HeLa cells); 32 μM (ATG9A KO HeLa cells)
Incubation Time: 4 h (eGFP-LC3 HeLa cells); 24 h (ATG9A KO HeLa cells)
Result: Induced perinuclear vacuole formation in eGFP-LC3 HeLa cells at 16 μM after 4 h.
Showed no vacuole formation in ATG9A KO HeLa cells at 32 μM after 24 h.
分子量

433.59

Formula

C27H35N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

501A054 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

501A0543080980-06-6AutophagyAutophagy activatorHeLa cells
Inhibitorinhibitorinhibit

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HY-181724
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