2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. NCX 1000

NCX 1000 是一种肝特异性 NO 供体，它来源于熊去氧胆酸。

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NCX 1000

NCX 1000 Chemical Structure

CAS No. : 401519-96-8

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥10962
In-stock
1 mg ￥2906
In-stock
5 mg 现货 询价
10 mg 现货 询价
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

NCX 1000 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

NCX 1000 is a liver-specific NO donor compound derived from ursodeoxycholic acid (UDCA).

IC50 & Target

Human Endogenous Metabolite

 

体内研究
(In Vivo)

NCX-1000 (15 mg/kg, p.o.) prevents ascite formation, reduces collagen deposition in CCl4-treated rats. NCX-1000 administration almost completely reverts portal hypertension induced by CCl4, and reduces portal pressure in cirrhotic rats. NCX-1000 reverts HSC contraction induced by FCS, and also inhibits MCP-1 release from HSCs stimulated with TNF-α and IFN-γ[1]. NCX-1000 (28 mg/kg, p.o.) decreases portal pressure without affecting mean arterial pressure and heart rate in rats. NCX-1000 also reduces vasoconstriction by 60% caused by 30 μM NE in rats. Administration of NCX-1000 to BDL and sham operated rats results in a similar increase of nitrite/nitrate and cGMP concentrations in the liver[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

685.84

Formula

C38H55NO10
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (145.81 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.4581 mL 7.2903 mL 14.5807 mL
5 mM 0.2916 mL 1.4581 mL 2.9161 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 98.91%

COA (263 KB) HNMR (323 KB) LCMS (103 KB)

产品使用指南 (1538 KB)
参考文献
Animal Administration
[1]

Rats: On the first protocol, 54 rats, 12 animals/group unless specified, are randomly allocated to receive one of the following treatments: group 1 has phenobarbital induction and no further treatment; group 2 (16 animals) is treated with CCl4 twice a week for 8 weeks; group 3 has CCl4 twice a week plus UDCA (15 mg/kg); and group 4 has CCl4 twice a week plus NCX-1000 (15 mg/kg). NCX-1000 and UDCA are dissolved in carboxymethyl cellulose and administered daily by gavage. Animal weight is monitored daily through the study period, and the dosage of CCl4 is adjusted accordingly to the animal weight. At the end of the treatment surviving animals are killed by an overdose of uretane, and blood, ascitic fluid, and livers are collected. A portion of each liver is fixed in 10% formalin for histological evaluation. The remaining tissue is partitioned and immediately stored under frozen liquid nitrogen at -80°C until used. On the second protocol, 74 rats are randomly allocated to receive the same treatments as protocol 1. At the end of the study, surviving animals are tested for portal and arterial pressure measurement.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

NCX 1000 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4581 mL 7.2903 mL 14.5807 mL 36.4516 mL
5 mM 0.2916 mL 1.4581 mL 2.9161 mL 7.2903 mL
10 mM 0.1458 mL 0.7290 mL 1.4581 mL 3.6452 mL
15 mM 0.0972 mL 0.4860 mL 0.9720 mL 2.4301 mL
20 mM 0.0729 mL 0.3645 mL 0.7290 mL 1.8226 mL
25 mM 0.0583 mL 0.2916 mL 0.5832 mL 1.4581 mL
30 mM 0.0486 mL 0.2430 mL 0.4860 mL 1.2151 mL
40 mM 0.0365 mL 0.1823 mL 0.3645 mL 0.9113 mL
50 mM 0.0292 mL 0.1458 mL 0.2916 mL 0.7290 mL
60 mM 0.0243 mL 0.1215 mL 0.2430 mL 0.6075 mL
80 mM 0.0182 mL 0.0911 mL 0.1823 mL 0.4556 mL
100 mM 0.0146 mL 0.0729 mL 0.1458 mL 0.3645 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NCX 1000401519-96-8NCX1000NCX-1000Endogenous MetaboliteInhibitorinhibitorinhibit

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