A 33903

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A 33903 是一种呼吸道合胞病毒 (RSV) 复制抑制剂。A 33903 可用于病毒感染方面的研究。

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A 33903 Chemical Structure

CAS No. : 70890-53-8

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生物活性

A 33903 is a respiratory syncytial virus (RSV) replication inhibitor. A 33903 can be used for the research of RSV-infection^[1].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
HEp-2	CC₅₀	> 50 μM Compound: A-33903	Cytotoxicity against RSV RSS infected human Hep2 cells after 6 days by XTT assay Cytotoxicity against RSV RSS infected human Hep2 cells after 6 days by XTT assay	[PMID: 17576833]
HEp-2	EC₅₀	10.1 μM Compound: A-33903	Antiviral activity against RSV RSS infected human Hep2 cells assessed as reduction of viral antigen synthesis after 3 days by ELISA Antiviral activity against RSV RSS infected human Hep2 cells assessed as reduction of viral antigen synthesis after 3 days by ELISA	[PMID: 17576833]
HEp-2	EC₅₀	15.1 μM Compound: A-33903	Antiviral activity against RSV A2 infected human Hep2 cells after 5 days by plaque reduction assay Antiviral activity against RSV A2 infected human Hep2 cells after 5 days by plaque reduction assay	[PMID: 17576833]
HEp-2	EC₅₀	27.6 μM Compound: A-33903	Antiviral activity against plaque picked A-33903-resistant RSV RSS from passage 2 in human Hep2 cells by plaque reduction assay Antiviral activity against plaque picked A-33903-resistant RSV RSS from passage 2 in human Hep2 cells by plaque reduction assay	[PMID: 17576833]
HEp-2	EC₅₀	3.5 μM Compound: A-33903	Antiviral activity against RSV B infected human Hep2 cells after 5 days by plaque reduction assay Antiviral activity against RSV B infected human Hep2 cells after 5 days by plaque reduction assay	[PMID: 17576833]
HEp-2	EC₅₀	7.2 μM Compound: A-33903	Antiviral activity against RSV Long infected human Hep2 cells after 5 days by plaque reduction assay Antiviral activity against RSV Long infected human Hep2 cells after 5 days by plaque reduction assay	[PMID: 17576833]
HEp-2	EC₅₀	8.1 μM Compound: A-33903	Antiviral activity against DMSO-passaged wild type RSV RSS infected human Hep2 cells by plaque reduction assay Antiviral activity against DMSO-passaged wild type RSV RSS infected human Hep2 cells by plaque reduction assay	[PMID: 17576833]
HEp-2	EC₅₀	9.6 μM Compound: A-33903	Antiviral activity against RSV RSS infected human Hep2 cells assessed as inhibition of virus-induced cell death after 6 days by XTT assay Antiviral activity against RSV RSS infected human Hep2 cells assessed as inhibition of virus-induced cell death after 6 days by XTT assay	[PMID: 17576833]
HEp-2	EC₅₀	9.7 μM Compound: A-33903	Antiviral activity against RSV RSS infected human Hep2 cells after 5 days by plaque reduction assay Antiviral activity against RSV RSS infected human Hep2 cells after 5 days by plaque reduction assay	[PMID: 17576833]
HEp-2	EC₅₀	> 100 μM Compound: A-33903	Antiviral activity against plaque picked RSV604-resistant RSV RSS from passage 2 in human Hep2 cells by plaque reduction assay Antiviral activity against plaque picked RSV604-resistant RSV RSS from passage 2 in human Hep2 cells by plaque reduction assay	[PMID: 17576833]
HEp-2	IC₅₀	17.6 μM Compound: 18	Antiviral activity against RSV Long in Hep2 cells by ELISA Antiviral activity against RSV Long in Hep2 cells by ELISA	[PMID: 16570927]
HEp-2	IC₅₀	17.8 μM Compound: 18	Antiviral activity against RSV B in Hep2 cells by ELISA Antiviral activity against RSV B in Hep2 cells by ELISA	[PMID: 16570927]
HEp-2	IC₅₀	3.6 μM Compound: 18	Antiviral activity against RSV B in Hep2 cells by plaque assay Antiviral activity against RSV B in Hep2 cells by plaque assay	[PMID: 16570927]
HEp-2	IC₅₀	7.1 μM Compound: 18	Antiviral activity against RSV RSS in Hep2 cells by plaque assay Antiviral activity against RSV RSS in Hep2 cells by plaque assay	[PMID: 16570927]
HEp-2	IC₅₀	7.2 μM Compound: 18	Antiviral activity against RSV Long in Hep2 cells by plaque assay Antiviral activity against RSV Long in Hep2 cells by plaque assay	[PMID: 16570927]
HEp-2	IC₅₀	8.6 μM Compound: 18	Antiviral activity against RSV RSS in Hep2 cells by whole cell XTT assay Antiviral activity against RSV RSS in Hep2 cells by whole cell XTT assay	[PMID: 16570927]
HEp-2	IC₅₀	9.3 μM Compound: 18	Antiviral activity against RSV RSS in Hep2 cells by ELISA Antiviral activity against RSV RSS in Hep2 cells by ELISA	[PMID: 16570927]
Sf9	IC₅₀	> 10 μM Compound: figure 3, R4C2	Displacement of [3H]Ro15-4513 from GABAA alpha-1-beta-2-gamma-2 receptor expressed in Sf9 baculovirus system Displacement of [3H]Ro15-4513 from GABAA alpha-1-beta-2-gamma-2 receptor expressed in Sf9 baculovirus system	[PMID: 18537233]
Sf9	IC₅₀	> 10 μM Compound: figure 3, R4C2	Displacement of [3H]Ro15-4513 from GABAA alpha-5-beta-2-gamma-2 receptor expressed in Sf9 baculovirus system Displacement of [3H]Ro15-4513 from GABAA alpha-5-beta-2-gamma-2 receptor expressed in Sf9 baculovirus system	[PMID: 18537233]

分子量

293.32

Formula

C₁₇H₁₅N₃O₂

CAS 号

70890-53-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Chapman J, et al. RSV604, a novel inhibitor of respiratory syncytial virus replication[J]. Antimicrobial agents and chemotherapy, 2007, 51(9): 3346-3353. [Content Brief]

A 33903 相关分类

Infection

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A 3390370890-53-8A33903A-33903RSVRespiratory syncytial virusrespiratory syncytial virusinfectionInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

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营业执照（三证合一）

A 33903

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A 33903

A 33903 相关抗体

A 33903 相关产品

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A 33903 相关分类

摩尔计算器

稀释计算器

The molarity calculator equation

The dilution calculator equation

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