2. Neuronal Signaling
  3. Amyloid-β
  4. Aβ aggregation-IN-5

Aβ aggregation-IN-5 是一种可穿透血脑屏障的 β-淀粉样蛋白 (amyloid-β) 聚集抑制剂。Aβ aggregation-IN-5 能抑制 Aβ 的聚集/寡聚化，挽救因 Aβ/ROS 毒性受损的细胞，并减少小胶质细胞活化及一氧化氮 (NO) 的产生。Aβ aggregation-IN-5 可降低 APP/PSEN1 小鼠模型中淀粉样蛋白负荷、神经炎症及小胶质细胞活化。Aβ aggregation-IN-5 可用于阿尔茨海默病的研究。

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Aβ aggregation-IN-5

Aβ aggregation-IN-5 Chemical Structure

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Aβ aggregation-IN-5 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Aβ aggregation-IN-5 is a brain-penetrant amyloid-β aggregation inhibitor. Aβ aggregation-IN-5 inhibits Aβ aggregation/oligomerization, rescues cells from AB/ROS toxicity and reduces microglial activation/NO production. Aβ aggregation-IN-5 reduces amyloid burden, neuroinflammation, microglial activation in APP/PSEN1 mice. Aβ aggregation-IN-5 can be used for the research of Alzheimer's disease[1].

体外研究
(In Vitro)

Aβ aggregation-IN-5 (Compound P4B) (20 µM；24–48 h) 可抑制 Aβ (10 µM) 的聚集/寡聚化[1]。
Aβ aggregation-IN-5 (10–20 μM；24–30 h) 可减轻 Aβ 和 ROS 诱导的 SH-SY5Y 细胞毒性[1]。
Aβ aggregation-IN-5 (10 µM；24 h) 可降低 N9 细胞中的小胶质细胞活化和 NO 生成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Aβ aggregation-IN-5 相关抗体:

Immunofluorescence[1]

Cell Line: N9 cells
Concentration: 10 µM
Incubation Time: 24 h
Result: Reduced Iba1 expression to basal level.
体内研究
(In Vivo)

Aβ aggregation-IN-5 (5 mg/kg；腹腔注射；每日；持续 60 天) 可改善老年 APP/PSEN1 小鼠模型中的 Aβ 沉积和炎症反应[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Transgenic APP/PSEN1 AD mice [B6.Cg-Tg-\r\n(APPswe,PSEN 1dE9)85Dbo/Mmjax][1]
Dosage: 5 mg/kg
Administration: i.p.; daily; 60 days
Result: Reduced amyloid burden in the hippocampus by ~1.3-fold and in the cortex by ~1.6-fold compared to the Alzheimer’s disease control group.
Reduced microglial activation marker Iba1 levels by ~0.8-fold in hippocampus and ~0.6-fold in cortex.
Decreased CD68 levels and colocalization of amyloid plaques with activated microglia.
Observed no significant body weight changes or microscopic pathological lesions in visceral organs.
分子量

563.64

Formula

C32H37NO8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Aβ aggregation-IN-5 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aβ aggregation-IN-5Amyloid-ββ-amyloid peptideAβAbetaneurodegenerative disordersoxidative stressAlzheimer's diseasemicroglialAPP/PSEN1SH-SY5YN9 cellInhibitorinhibitorinhibit

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