2. 疾病领域
  3. 神经系统疾病
  4. 神经退行性疾病
  5. 阿尔茨海默病
  6. Aβ aggregation-IN-6

Aβ aggregation-IN-6 (compound 4) 是一种 Aβ 聚集抑制剂，对 Aβ17-40 聚集的抑制率约为 60-70%。Aβ aggregation-IN-6 可稳定 Aβ 二聚体组装体、结合 Aβ 空间拉链组装体，并干扰其聚集为更高阶的毒性物种。Aβ aggregation-IN-6 可用于阿尔茨海默病的研究。

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Aβ aggregation-IN-6

Aβ aggregation-IN-6 Chemical Structure

CAS No. : 439932-74-8

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Aβ aggregation-IN-6 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Aβ aggregation-IN-6 (compound 4) is an Aβ aggregation inhibitor with ~60-70% inhibition of Aβ17-40 aggregation. Aβ aggregation-IN-6 stabilizes Aβ dimer assembly, binds to Aβ steric-zipper assembly, and interferes with aggregation into higher-order toxic species. Aβ aggregation-IN-6 can be used for the research of alzheimer's disease[1].

体外研究
(In Vitro)

Aβ aggregation-IN-6 (compound 4) 通过多种极性与非极性相互作用稳定 Aβ 二聚体组装体，其 CDOCKER 相互作用能为-18.93 kcal/mol，从而抑制 Aβ 的进一步聚集[1]。
Aβ aggregation-IN-6 通过多种有利相互作用结合于 Aβ 空间拉链组装体，其 CDOCKER 相互作用能为 -30.48 kcal/mol，从而稳定该组装体并降低 Aβ 聚集体的细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Aβ aggregation-IN-6 相关抗体:
分子量

391.33

Formula

C15H16Cl2N2O2S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Aβ aggregation-IN-6 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aβ aggregation-IN-6439932-74-8Aβ steric-zipper assemblyAβ aggregationAβ dimer assemblyAβ17-40Aβ aggregate cytotoxicityalzheimer's diseaseInhibitorinhibitorinhibit

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