2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. ABI-274

ABI-274 是一种微管蛋白和秋水仙碱结合位点抑制剂。ABI-274 与维莫非尼 (HY-12057) 联合使用时，可在体外显著促进癌细胞凋亡。ABI-274 在裸鼠维莫非尼耐药异种移植模型中表现出强大的协同疗效。ABI-274 可用于黑色素瘤相关研究。

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ABI-274

ABI-274 Chemical Structure

CAS No. : 1253697-93-6

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ABI-274 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ABI-274 is a tubulin and colchicine binding site inhibitor. ABI-274 significantly promotes cancer cell apoptosis in vitro when combined with vemurafenib (HY-12057). ABI-274 exhibits potent synergistic efficacy in the vemurafenib-resistant xenograft model in nude mice. ABI-274 can be studied in research on melanoma[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A-375 IC50
18.7 nM
Compound: ABI-274
Antiproliferative activity against human A375 cells measured after 72 hrs by MTS assay
Antiproliferative activity against human A375 cells measured after 72 hrs by MTS assay
[PMID: 31860298]
A-375 IC50
9 nM
Compound: 5da
Cytotoxicity against human A375 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human A375 cells after 48 hrs by sulforhodamine B assay
[PMID: 20919720]
A-375 IC50
9 nM
Compound: 5da3
Cytotoxicity against human A375 cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human A375 cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 23547728]
B16-F1 IC50
46 nM
Compound: 5da
Cytotoxicity against mouse B16-F1 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against mouse B16-F1 cells after 48 hrs by sulforhodamine B assay
[PMID: 20919720]
DU-145 IC50
11 nM
Compound: 5da3
Cytotoxicity against human DU145 cells assessed as growth inhibition after 96 hrs by SRB assay
Cytotoxicity against human DU145 cells assessed as growth inhibition after 96 hrs by SRB assay
[PMID: 23547728]
DU-145 IC50
15 nM
Compound: 5da
Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay
[PMID: 20919720]
LNCaP IC50
12 nM
Compound: 5da
Cytotoxicity against human LNCAP cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human LNCAP cells after 48 hrs by sulforhodamine B assay
[PMID: 20919720]
LNCaP IC50
12 nM
Compound: 5da3
Cytotoxicity against human LNCAP cells assessed as growth inhibition after 96 hrs by SRB assay
Cytotoxicity against human LNCAP cells assessed as growth inhibition after 96 hrs by SRB assay
[PMID: 23547728]
M14 IC50
6.9 nM
Compound: ABI-274
Antiproliferative activity against human M14 cells measured after 72 hrs by MTS assay
Antiproliferative activity against human M14 cells measured after 72 hrs by MTS assay
[PMID: 31860298]
MDA-MB-231 IC50
25.3 nM
Compound: ABI-274
Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTS assay
Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTS assay
[PMID: 31860298]
MDA-MB-435 IC50
5 nM
Compound: 5da3
Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay
Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay
[PMID: 23547728]
MDA-MB-453 IC50
11.4 nM
Compound: ABI-274
Antiproliferative activity against human MDA-MB-453 cells measured after 72 hrs by MTS assay
Antiproliferative activity against human MDA-MB-453 cells measured after 72 hrs by MTS assay
[PMID: 31860298]
PC-3 IC50
9 nM
Compound: 5da
Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay
[PMID: 20919720]
PC-3 IC50
9 nM
Compound: 5da3
Cytotoxicity against human PC3 cells assessed as growth inhibition after 96 hrs by SRB assay
Cytotoxicity against human PC3 cells assessed as growth inhibition after 96 hrs by SRB assay
[PMID: 23547728]
PPC-1 IC50
11 nM
Compound: 5da
Cytotoxicity against human PPC1 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human PPC1 cells after 48 hrs by sulforhodamine B assay
[PMID: 20919720]
PPC-1 IC50
15 nM
Compound: 5da3
Cytotoxicity against human PPC1 cells assessed as growth inhibition after 96 hrs by SRB assay
Cytotoxicity against human PPC1 cells assessed as growth inhibition after 96 hrs by SRB assay
[PMID: 23547728]
RPMI-7951 IC50
6.4 nM
Compound: ABI-274
Antiproliferative activity against human RPMI7951 cells measured after 72 hrs by MTS assay
Antiproliferative activity against human RPMI7951 cells measured after 72 hrs by MTS assay
[PMID: 31860298]
SK-BR-3 IC50
12.5 nM
Compound: ABI-274
Antiproliferative activity against human SK-BR-3 cells measured after 72 hrs by MTS assay
Antiproliferative activity against human SK-BR-3 cells measured after 72 hrs by MTS assay
[PMID: 31860298]
WM164 IC50
8 nM
Compound: 5da
Cytotoxicity against human WM164 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human WM164 cells after 48 hrs by sulforhodamine B assay
[PMID: 20919720]
分子量

352.38

Formula

C20H20N2O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ABI-274 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ABI-2741253697-93-6ABI274ABI 274Microtubule/TubulinInhibitorinhibitorinhibit

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ABI-274
目录号：
HY-W674149
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