2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. AChE-IN-109

AChE-IN-109 是一种强效的混合型胆碱酯酶抑制剂，对 AChE 的抑制活性显著强于 BChE。AChE-IN-109 对 AChE 和 BChE 的 IC50 值分别为 0.55 μM 和 12.45 μM。AChE-IN-109 通过混合型机制抑制胆碱酯酶，可结合 AChE 的催化活性位点 (CAS) 和外周阴离子位点 (PAS)。AChE-IN-109 可用于阿尔茨海默病 (AD) 的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

AChE-IN-109

AChE-IN-109 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

AChE-IN-109 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

查看所有亚型
AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AChE-IN-109 is a potent mixed-type cholinesterase inhibitor with significantly stronger inhibitory activity against AChE than BChE. AChE-IN-109 has IC50 values of 0.55 μM and 12.45 μM against AChE and BChE, respectively. AChE-IN-109 inhibits cholinesterases through a mixed-type mechanism, binds to both the catalytic active site (CAS) and peripheral anionic site (PAS) of AChE. AChE-IN-109 can be used for the study of Alzheimer’s disease (AD)[1].

IC50 & Target[1]

AChE

0.55 μM (IC50)

BChE

12.45 μM (IC50)

体外研究
(In Vitro)

AChE-IN-109 (11n) (预孵育 10 分钟；反应 10 分钟) 可强效抑制电鳗乙酰胆碱酯酶，其 IC50 为 0.55 μM，同时抑制马血清丁酰胆碱酯酶，IC50 为 12.45 μM，对马血清丁酰胆碱酯酶的选择性达 22.43 倍[1]。
AChE-IN-109 是一种混合型抑制剂，可结合乙酰胆碱酯酶 (AChE) 的催化活性位点 (CAS) 和外周阴离子位点 (PAS)[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AChE-IN-109 相关抗体:
分子量

497.59

Formula

C28H31N7O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AChE-IN-109 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE-IN-109Cholinesterase (ChE)catalytic anionic site (CAS)Saccharomyces cerevisiaehorse BChEalzheimer’s diseasebutyrylcholinesteraseelectric eel AChEacetylcholinesteraseperipheral anionic site (PAS)Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
AChE-IN-109
目录号：
HY-181851
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z