2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. ACT-774312

ACT-774312 是一种强效的、选择性的 CRTH2 拮抗剂，其 IC50 为 4 nM。ACT-774312 可阻断 CRTH2 受体的活性与内化过程，并抑制 PGD2 诱导的嗜酸性粒细胞形态改变。ACT-774312 可用于鼻息肉以及 2 型炎症性疾病的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

ACT-774312

ACT-774312 Chemical Structure

CAS No. : 1809863-68-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

ACT-774312 相关抗体

Top Publications Citing Use of Products

查看 Prostaglandin Receptor 亚型特异性产品:

查看所有亚型
DP EP FP IP TXA2/TP TXB2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ACT-774312 is a potent and selective CRTH2 antagonist with an IC50 of 4 nM. ACT-774312 blocks the activity and internalization of the CRTH2 receptor, and inhibits PGD2-induced morphological changes in eosinophils. ACT-774312 can be used in the research of nasal polyps and type 2 inflammatory diseases.[1][2]

体外研究
(In Vitro)

ACT-774312 可在含 50% 人血浆的条件下强效抑制 PGD2 诱导的嗜酸性粒细胞形态改变，其 IC50 为 3 nM[1][2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ACT-774312 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route AUC0-∞ CL Vss T1/2 Cmax Tmax F
Rat[1] 1 mg/kg i.v. 4.05 μg·h/mL 4.1 0.45 L/kg 3.2 h / / /
Rat[1] 2 mg/kg p.o. 8.43 μg·h/mL / / / 1.29 μg/mL 0.3 h 104 %
Dog[1] 1 mg/kg i.v. 9.24 μg·h/mL 1.8 0.45 L/kg 5.7 h / / /
Dog[1] 2 mg/kg p.o. 7.24 μg·h/mL / / / 2.41 μg/mL 1 h 78 %
分子量

389.81

Formula

C18H17ClFN5O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ACT-774312 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ACT-7743121809863-68-0ACT774312ACT 774312Prostaglandin Receptorhuman liver microsomesDP1 receptordog liver microsomesCRTH2 receptorcytochrome P450 enzymeeosinophilhERG channelrat liver microsomesPGD2pregnane X receptorInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
ACT-774312
目录号：
HY-182637
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z