2. Neuronal Signaling Stem Cell/Wnt MAPK/ERK Pathway Apoptosis Immunology/Inflammation
  3. Cholinesterase (ChE) Amyloid-β ERK TNF Receptor Interleukin Related
  4. AD-35

AD-35 是一种口服有效的抗阿尔茨海默病 (AD) 剂，具有适度的 AChE 抑制活性和金属离子螯合能力。AD-35 对 AChE 和 BuChE 的 IC50 为 793 nM 和 31428 nM。AD-35 能与 Cu²⁺ 和 Fe³⁺ 形成螯合物，但对 Zn²⁺ 的螯合能力较弱。AD-35 可抑制 Aβ 聚集，并解聚已形成的 Aβ 聚集体，抑制 Aβ 诱导的 ERK 磷酸化。AD-35 在 AD 大鼠模型中抑制了神经炎症并在展示出强大的改善认知功能作用。

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AD-35

AD-35 Chemical Structure

CAS No. : 1531586-64-7

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AD-35 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

查看 ERK 亚型特异性产品:

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ERK ERK1 ERK2 ERK5 ERK8

查看 TNF Receptor 亚型特异性产品:

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TNFRSF1A/CD120a TNFRSF3/CD18 TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AD-35 is an orally active anti-Alzheimer's disease (AD) agent with moderate AChE inhibitory activity and metal ion chelating ability. AD-35 exhibits IC50 values for AChE and BuChE of 793 nM and 31428 nM, respectively. AD-35 can form chelates with Cu²⁺ and Fe³⁺, but its chelating ability for Zn²⁺ is relatively weak. AD-35 can inhibit Aβ aggregation and disassemble the formed Aβ aggregates, and inhibit Aβ-induced ERK phosphorylation. AD-35 inhibits neuroinflammation in AD rat models and demonstrates a strong effect in improving cognitive function[1].

IC50 & Target[1]

AChE

793 nM (IC50)

IL-1β

 

分子量

503.48

Formula

C24H30N3O7P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AD-35 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AD-351531586-64-7AD35AD 35Cholinesterase (ChE)Amyloid-βERKTNF ReceptorInterleukin Relatedβ-amyloid peptideAβAbetaExtracellular signal regulated kinasesTumor Necrosis Factor ReceptorTNFRILAlzheimer's diseaseamyloid-βcognitive impairmentmetal ionsneuroinflammatory responseInhibitorinhibitorinhibit

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HY-117710B
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