2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. AGH-194

AGH-194 是一种 5-HT7 受体激动剂，Ki 为 2 nM。AGH-194 激活与神经保护和神经突生长相关的 Gs 蛋白偶联信号通路，刺激神经元细胞的神经突生长。AGH-194 可降低未分化神经元细胞中的细胞损伤关。AGH-194 可用于神经退行性疾病的研究。

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AGH-194

AGH-194 Chemical Structure

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Customer Review

AGH-194 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AGH-194 is a 5-HT7 receptor agonist with a Ki value of 2 nM. AGH-194 activates Gs protein-coupled signaling pathways associated with neuroprotection and neurite outgrowth, and stimulates neurite outgrowth in neuronal cells. AGH-194 reduces cell damage in undifferentiated neuronal cells. AGH-194 can be used in the research of neurodegenerative diseases[1].

IC50 & Target[1]

5-HT7 Receptor

2 nM (Ki)

体外研究
(In Vitro)

AGH-194 (0.1-80 μM; 24-72 h) 可在 UN-SH-SY5Y 细胞中诱导浓度和时间依赖性的细胞毒性，并降低细胞活力，对 UN-和 RA-SH-SY5Y 细胞均能诱导显著的细胞毒性，在 SH-SY5Y 细胞中诱导细胞活力呈时间和浓度依赖性降低[1]。
AGH-194 (0.01-1 μM; 30 min pre-incubation, 24 h co-incubation with H2O2) 在 0.1 μM 浓度下可部分减轻在 NB 中培养、遭受 H2O2 诱导损伤的 UN-SH-SY5Y 细胞的细胞毒性，但无法逆转其细胞活力的丧失[1]。
AGH-194 (0.01-0.1 μM; 24 h) 刺激 SH-SY5Y 细胞的轴突生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AGH-194 相关抗体:

Cell Viability Assay[1]

Cell Line: Undifferentiated human neuroblastoma UN-SH-SY5Y cells (DMEM experimental medium)
Concentration: 0.1, 1, 10, 20, 40, 80 μM
Incubation Time: 24 h, 48 h
Result: Caused a concentration- and time-dependent decrease in cell viability, with maximum damage observed at 40 and 80 μM; viability was more reduced at 48 h than 24 h for 20 and 40 μM.
Increased LDH release ~2-4-fold at 40 and 80 μM after 24 h.
Increased LDH release ~1.5-3-fold at 10, 20, 40, 80 μM after 48 h.
Showed higher LDH release at 48 h than 24 h for 20 and 40 μM, but higher at 24 h than 48 h for 80 μM.

Cell Viability Assay[1]

Cell Line: Undifferentiated human neuroblastoma UN-SH-SY5Y cells, retinoic acid-differentiated RA-SH-SY5Y cells (NB experimental medium)
Concentration: 1-20 μM
Incubation Time: 24 h
Result: Caused a significant ~18% decrease in cell viability at 20 μM in UN-SH-SY5Y cells.
Caused a significant ~15.7% decrease in cell viability at 10 μM in RA-SH-SY5Y cells.
Caused a significant ~22.95% decrease in cell viability at 20 μM in RA-SH-SY5Y cells.

Cell Proliferation Assay[1]

Cell Line: Human neuroblastoma SH-SY5Y cells (DMEM with 10% FBS)
Concentration: 0.001, 0.01, 0.1, 1, 10, 20, 40, 80 μM
Incubation Time: 24 h, 48 h, 72 h
Result: Caused a time- and concentration-dependent reduction in cell viability.
Induced maximal cell damage at 80 μM after 24 h, with similar effects at 48 and 72 h.
Caused concentration-dependent decreases in cell viability (up to ~20%) at 10, 20, 40 μM at 48 h, with greater effects than at 24 h.
Caused a significantly greater reduction in cell viability at 40 μM at 72 h than at 48 h.
分子量

377.58

Formula

C12H10ClFIN3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AGH-194 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AGH-194AGH194AGH 1945-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT7 receptor agonistSH-SY5Y cellsneurodegenerative diseasesInhibitorinhibitorinhibit

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目录号：
HY-181984
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