2. Protein Tyrosine Kinase/RTK
  3. Anaplastic lymphoma kinase (ALK)
  4. ALK-IN-35

ALK-IN-35 是一种 ALK 降解剂，其 IC50 为 0.74 nM。ALK-IN-35 可抑制 ALK 激酶活性，增加 ALK 结合口袋附近疏水残基的溶剂可及表面积，促进 ALK 形成部分去折叠构象，并诱导 ALK 发生蛋白酶体降解。ALK-IN-35 可抑制癌细胞增殖。ALK-IN-35 可用于非小细胞肺癌的相关研究。

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ALK-IN-35

ALK-IN-35 Chemical Structure

CAS No. : 3111011-76-5

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ALK-IN-35 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ALK-IN-35 is a ALK degrader with an IC50 of 0.74 nM. ALK-IN-35 inhibits ALK kinase activity, increases the solvent-accessible surface area of hydrophobic residues near the ALK binding pocket, promotes ALK to form a partially unfolded conformation, and induces proteasomal degradation of ALK. ALK-IN-35 inhibits cancer cell proliferation. ALK-IN-35 can be used in research related to non-small cell lung cancer[1].

体外研究
(In Vitro)

ALK-IN-35 (compound B7) (7 天) 可强效抑制 H3122 细胞的增殖，其 IC50 为 68.98 nM[1]。
ALK-IN-35 (0.05-2 μM; 24 h) 可在 H3122 细胞中诱导 ALK 蛋白呈浓度依赖性降解[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ALK-IN-35 相关抗体:

Western Blot Analysis[1]

Cell Line: H3122 cells
Concentration: 0.05, 0.1, 0.5, 1, 2 μM
Incubation Time: 24 h
Result: Reduced ALK protein levels in H3122 cells in a concentration-dependent manner.
分子量

690.21

Formula

C36H45ClN7O3P
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ALK-IN-35 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALK-IN-353111011-76-5Anaplastic lymphoma kinase (ALK)Anaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246hydrophobic residuesnon-small-cell lung cancerproteasomal ALK degradationALK proteinALKcancer cellsEML4-ALK fusion proteinALK binding pocketH3122 cellsALK kinase activityInhibitorinhibitorinhibit

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