2. Cytoskeleton
  3. Integrin
  4. α5β1 integrin-IN-1

α5β1 integrin-IN-1 (compound 65) 是一种强效且选择性的 α5β1 整合素抑制剂，其 pIC50 值为 9.4。α5β1 integrin-IN-1 对 α5β1 的选择性比对 αVβ3 的选择性高 10000 倍以上 (αVβ3 的 pIC50 值为 5.5)。α5β1 integrin-IN-1 通过破坏细胞间连接来降低气道平滑肌 (ASM) 张力。α5β1 integrin-IN-1 在啮齿动物中表现出优异的吸入药代动力学特性。α5β1 integrin-IN-1 可用于哮喘研究。

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α5β1 integrin-IN-1

α5β1 integrin-IN-1 Chemical Structure

CAS No. : 2649899-08-9

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α5β1 integrin-IN-1 相关抗体

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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生物活性

α5β1 integrin-IN-1 (compound 65) is a potent and selective α5β1 integrin inhibitor with a pIC50 of 9.4. α5β1 integrin-IN-1 displays >10000-fold selectivity for α5β1 over αVβ3 (pIC50 = 5.5). α5β1 integrin-IN-1 reduces airway smooth muscle (ASM) tension through the disruption of cellular tethering. α5β1 integrin-IN-1 exhibits excellent inhalation pharmacokinetics in rodent. α5β1 integrin-IN-1 can be used for asthma research[1].

IC50 & Target[1]

α5β1

9.4 (pIC50)

αvβ3

5.5 (pIC50)

分子量

629.47

Formula

C29H27Cl2FN6O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

α5β1 integrin-IN-1 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

α5β1 integrin-IN-12649899-08-9Integrinintegrinairway smooth muscleinhalation pharmacokineticsrodentasthmaInhibitorinhibitorinhibit

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