2. Metabolic Enzyme/Protease
  3. PGC-1α
  4. AM31

AM31 是一种 PGC-1α1 稳定剂。AM31 可提高 PGC-1α1 蛋白稳定性，促进蛋白积累及靶基因激活。AM31 可诱导棕色脂肪细胞中 Ucp1 和 Cidea 的表达。AM31 可提高棕色脂肪细胞的基础线粒体呼吸及解偶联呼吸水平。AM31 可用于肥胖及相关代谢紊乱的研究。

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AM31

AM31 Chemical Structure

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Customer Review

AM31 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AM31 is a PGC-1α1 stabilizer. AM31 enhances the protein stability of PGC-1α1, promotes protein accumulation and target gene activation. AM31 induces the expression of Ucp1 and Cidea in brown adipocytes. AM31 increases the levels of basal mitochondrial respiration and uncoupled respiration in brown adipocytes. AM31 can be used for the research of obesity and related metabolic disorders[1].

体外研究
(In Vitro)

AM31 (10 μM; 8 h) 可在 HEK 293-EGFPmPGC-1α1 细胞中稳定 EGFP-PGC-1α1 融合蛋白[1]。
AM31 (10 μM; 8 h) 可在完全分化的小鼠永生化棕色脂肪细胞中激活 PGC-1α 靶基因的表达[1]。
AM31 (10 μM; 8 h) 在经 10 μM 处理 8 小时后，可稳定完全分化的小鼠永生化棕色脂肪细胞中的内源性 PGC-1α 蛋白[1]。
AM31 (10 μM; 8 h) 可在以 10 μM 处理完全分化的小鼠永生化棕色脂肪细胞 8 小时后，提升基础线粒体呼吸和解偶联线粒体呼吸水平，其中解偶联呼吸提升幅度达 38%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AM31 相关抗体:

Real Time qPCR[1]

Cell Line: fully differentiated mouse immortalized brown adipocytes
Concentration: 10 μM
Incubation Time: 8 h
Result: Induced a 12-fold increase in Ucp1 gene expression relative to DMSO control.
Induced a 4-fold increase in Cidea gene expression relative to DMSO control.
Induced smaller increases in expression of other PGC-1α target genes including Tra2, Fsp27, Cytc, Tfam, Cpt1b, Esrra, Prdm16, Pparg, and Sod1 relative to DMSO control.

Western Blot Analysis[1]

Cell Line: fully differentiated mouse immortalized brown adipocytes
Concentration: 10 μM
Incubation Time: 8 h
Result: Induced accumulation of endogenous PGC-1α protein, with levels comparable to those induced by isoproterenol treatment and lower than MG132-induced levels.
分子量

359.31

Formula

C17H12F3N5O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AM31 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AM31AM 31AM-31PGC-1αPPARγ coactivator-1αobesityCideaPGC-1α1metabolic disordersUcp1HEK 293-EGFPmPGC-1α1 cellsmouse immortalized brown adipocytesbrown adipocytesmitochondrial respirationInhibitorinhibitorinhibit

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目录号：
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