2. Metabolic Enzyme/Protease
  3. PGC-1α
  4. AM73

AM73 是一种 PGC-1α1 稳定剂。AM73 可提高棕色脂肪细胞中 Ucp1、Cidea 的表达水平，增强基础线粒体呼吸及解偶联呼吸。AM73 可调控棕色脂肪细胞中的缺氧、棕色脂肪分化、碳水化合物代谢及胰岛素信号通路。AM73 可改变白色脂肪细胞的产热过程。AM73 可用于肥胖及相关代谢紊乱的研究。

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AM73

AM73 Chemical Structure

CAS No. : 931619-99-7

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AM73 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AM73 is a PGC-1α1 stabilizer. AM73 increases the expression levels of Ucp1 and Cidea in brown adipocytes, and enhances basal mitochondrial respiration and uncoupled respiration. AM73 regulates hypoxia, brown adipocyte differentiation, carbohydrate metabolism and insulin signaling pathways in brown adipocytes. AM73 alters the thermogenic process of white adipocytes. AM73 is applicable to the research of obesity and related metabolic disorders[1].

体外研究
(In Vitro)

AM73 (10 μM; 8 h) 可升高 HEK 293-EGFPmPGC-1α1 细胞中 EGFP-PGC-1α1 融合蛋白的水平[1]。
AM73 (10 μM; 8 h) 可在完全分化的小鼠永生化棕色脂肪细胞中诱导产热及线粒体 PGC-1α 靶基因的显著表达[1]。
AM73 (10 μM; 8 h) 可稳定完全分化的小鼠永生化棕色脂肪细胞中的内源性 PGC-1α 蛋白[1]。
AM73 (10 μM; 8 h) 可使完全分化的小鼠永生化棕色脂肪细胞的基础线粒体呼吸和解偶联线粒体呼吸提升约 13%[1]。
AM73 (10 μM; 8 h) 调控完全分化的小鼠永生化棕色脂肪细胞中与产热、代谢及分化相关的大量 PGC-1α 关联基因通路[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AM73 相关抗体:

Immunofluorescence[1]

Cell Line: human embryonic kidney (HEK) 293-EGFPmPGC-1α1 stable cells (expressing EGFP-PGC-1α1 fusion protein)
Concentration: 10 μM
Incubation Time: 8 h
Result: Induced a 206.1% EGFP intensity increase relative to DMSO control, as measured by whole cell integrated fluorescence intensity median per well.

Real Time qPCR[1]

Cell Line: fully differentiated mouse immortalized brown adipocytes
Concentration: 10 μM
Incubation Time: 8 h
Result: Induced a 12-fold increase in Ucp1 gene expression, a ~4-fold increase in Cidea gene expression, and modest (≤2-fold) increases in the expression of other PGC-1α target genes including Tfam, Esrra, Prdm16, and Sod1, relative to DMSO control.

Western Blot Analysis[1]

Cell Line: fully differentiated mouse immortalized brown adipocytes
Concentration: 10 μM
Incubation Time: 8 h
Result: Increased endogenous PGC-1α protein accumulation to levels comparable to cold-induced brown adipose tissue, as detected by immunoblotting.
分子量

372.76

Formula

C18H13ClN2O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AM73 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AM73931619-99-7AM 73AM-73PGC-1αPPARγ coactivator-1αPGC-1α1 stabilizerHEK 293-EGFPmPGC-1α1 cellsmouse brown adipocytesobesityInhibitorinhibitorinhibit

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