2. AM79

AM79 是一种 PGC-1α1 稳定剂。AM79 促进内源性 PGC-1α1 蛋白的积累，进而激活其靶基因。AM79 可增加棕色脂肪细胞的解偶联线粒体呼吸。AM79 可诱导棕色脂肪细胞中 Ucp1 和 Cidea 的表达。AM79 可用于肥胖及相关代谢紊乱的研究。

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AM79

AM79 Chemical Structure

CAS No. : 949229-08-7

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AM79 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AM79 is a PGC-1α1 stabilizer. AM79 promotes the accumulation of endogenous PGC-1α1 protein, thereby activating its target genes. AM79 increases uncoupled mitochondrial respiration in brown adipocytes. AM79 induces the expression of Ucp1 and Cidea in brown adipocytes. AM79 can be used for the research of obesity and related metabolic disorders[1].

体外研究
(In Vitro)

AM79 (10 μM; 8 h) 可增强 HEK 293-EGFPmPGC-1α1 细胞中 EGFP-PGC-1α1 的荧光强度，表明 PGC-1α1 融合蛋白得到稳定，相对于蛋白酶体抑制的激活率为 57.1%[1]。
AM79 (10 μM; 8 h) 在完全分化的小鼠永生化棕色脂肪细胞中可显著诱导产热及线粒体靶基因的表达 (包括 Ucp1 的表达上调)，且不会改变 PGC-1α 基因的总表达量[1]。
AM79 (10 μM; 8 h) 可在完全分化的小鼠永生化棕色脂肪细胞中稳定内源性 PGC-1α 蛋白[1]。
AM79 (10 μM; 8 h) 可提高完全分化的小鼠永生化棕色脂肪细胞的基础线粒体呼吸和解偶联线粒体呼吸 (质子泄漏增加 12%)，且对最大呼吸能力无影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AM79 相关抗体:

Real Time qPCR[1]

Cell Line: fully differentiated mouse immortalized brown adipocytes
Concentration: 10 μM
Incubation Time: 8 h
Result: Induced a >10-fold increase in Ucp1 expression relative to DMSO control.
Induced a ~4-fold increase in Cidea expression relative to DMSO control.
Induced modest increases in Cytc, Tfam, Esrra, Prdm16, and Sod1 expression relative to DMSO control.
Left total Ppargc1a (PGC-1α) expression unchanged relative to control.

Western Blot Analysis[1]

Cell Line: fully differentiated mouse immortalized brown adipocytes
Concentration: 10 μM
Incubation Time: 8 h
Result: Increased endogenous PGC-1α protein levels in brown adipocytes to levels comparable to isoproterenol treatment and lower than MG132-induced stabilization.
分子量

412.48

Formula

C25H24N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AM79 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AM79949229-08-7AM 79AM-79mouse immortalized brown adipocytesHEK 293-EGFPmPGC-1α1 cellsUcp1PGC-1α1PGC-1α1 stabilizerInhibitorinhibitorinhibit

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