2. Antibody-drug Conjugate/ADC Related Immunology/Inflammation Cell Cycle/DNA Damage Cytoskeleton
  3. Antibody-Drug Conjugates (ADCs) Transmembrane Glycoprotein Microtubule/Tubulin
  4. AMG-172

AMG-172 是一种抗体偶联活性分子 (ADC)，由全人源 IgG1 单克隆抗 CD27L 抗体通过不可切割连接子 MCC 与 DM1 偶联而成。AMG 172 经分解代谢释放出胞内活性成分 Lysine-MCC-DM。Lysine-MCC-DM 可抑制 Microtubule 的组装与解聚动态，并诱导细胞阻滞于中期。AMG-172 可用于复发/难治性透明细胞肾细胞癌的研究。
(粉色: 靶蛋白配体；蓝色: E3 连接酶配体；黑色: 连接子)。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

AMG-172

AMG-172 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货
1 mg ￥6750
询问价格 & 货期
5 mg 询价 询问价格 & 货期

* Please select Quantity before adding items.

Customer Review

AMG-172 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AMG-172 is an antibody-drug conjugate (ADC) composed of a fully human IgG1 monoclonal anti-CD27L antibody conjugated to DM1 via the non-cleavable linker MCC. AMG-172 releases the intracellular active component Lysine-MCC-DM through catabolism. Lysine-MCC-DM inhibits the assembly and disassembly dynamics of Microtubule and induces cell arrest at metaphase. AMG-172 can be used for research on relapsed/refractory clear cell renal cell carcinoma[1]. (Pink: Target protein ligand; Blue: E3 ligase ligand; Black: linker).

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AMG-172 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMG-172AMG172AMG 172Antibody-Drug Conjugates (ADCs)Transmembrane GlycoproteinMicrotubule/TubulinAntibody-Drug ConjugatesIgG1 monoclonal anti-CD27L antibodymetaphase arrestMCCrelapsed/refractory clear cell renal cell carcinomaantibody-drug conjugatemicrotubule assembly/disassembly dynamicsCD27L-expressing cellsmaytansinoid cytotoxin DM1Inhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
AMG-172
目录号：
HY-185483
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z