2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. AMG-8562

AMG-8562 是一种 TRPV1 调节剂。AMG-8562 可阻断 Capsaicin (HY-10448) 对 TRPV1 的激活，但不影响热激活。AMG-8562 可增强 pH 5 对 TRPV1 的激活。AMG-8562 在疼痛模型中可阻断 Capsaicin 诱导的畏缩行为。AMG-8562 在 CFA 和皮肤切口诱导的热痛觉过敏以及 Acetic acid (HY-Y0319) 诱导的扭体模型中均显示出显著疗效。

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AMG-8562

AMG-8562 Chemical Structure

CAS No. : 1041478-78-7

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AMG-8562 相关抗体

Top Publications Citing Use of Products

查看 TRP Channel 亚型特异性产品:

查看所有亚型
TRPA1 TRPC3 TRPC4 TRPC5 TRPM8 TRPM2 TRPM3 TRPM4 TRPML1 TRPML2 TRPML3 TRPV1 TRPV2 TRPV3 TRPV4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AMG-8562 is a TRPV1 modulator. AMG-8562 blocks Capsaicin (HY-10448) activation of TRPV1 without affecting heat activation of TRPV1. AMG-8562 potentiates pH 5 activation of TRPV1. AMG-8562 blocks capsaicin-induced flinching behavior in pain models. AMG-8562 produces significant efficacy in CFA- and skin incision-induced thermal hyperalgesia, and in the Acetic acid (HY-Y0319)-induced writhing models[1].

IC50 & Target[1]

TRPV1

 

分子量

430.47

Formula

C24H25F3N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AMG-8562 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMG-85621041478-78-7AMG8562AMG 8562TRP ChannelTransient receptor potential channelswrithing modelsthermal hyperalgesiaInhibitorinhibitorinhibit

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产品名称：
AMG-8562
目录号：
HY-114583
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