2. Apoptosis Metabolic Enzyme/Protease
  3. Glutathione Peroxidase
  4. Aminopyridine 2

Aminopyridine 2 是一种不可逆地、选择性和具有口服活性的髓过氧化物酶 (MPO) 抑制剂，其对人 MPO 的 IC50 为 0.16 μM，Ki 为 24 μM。Aminopyridine 2 可作用于在慢性炎症疾病研究。

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Aminopyridine 2

Aminopyridine 2 Chemical Structure

CAS No. : 2411643-58-6

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Aminopyridine 2 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Aminopyridine 2 is an irreversible, selective, and orally active myeloperoxidase (MPO) inhibitor, with an IC50 of 0.16 μM and a Ki of 24 μM against human MPO. Aminopyridine 2 is applicable to research on chronic inflammatory diseases[1].

体外研究
(In Vitro)

Aminopyridine 2 (2 小时) 可抑制血浆中人 MPO 的活性，其表观 IC50 为 1.9 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Aminopyridine 2 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route Cmax Tmax AUC0-∞ Bioavailability
Mice[1] 10 mg/kg p.o. 11884 nM 1.3 h 58440 nM·h/mL 51 %
Rat[1] 10 mg/kg p.o. 20844 nM 0.4 h 133162 nM·h/mL ~100 %
Dog[1] 10 mg/kg p.o. 19486 nM 2.3 h 335615 nM·h/mL ~100 %
体内研究
(In Vivo)

Aminopyridine 2 (2.5-100 mg/kg；灌胃；单次给药) 可在小鼠腹膜炎模型中剂量依赖性地抑制 MPO 活性[1]。
Aminopyridine 2 (~50-200 mg/kg；食物混饲，14 天) 在小鼠腹膜炎模型中呈剂量依赖性抑制 MPO 活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (male, 8 weeks old)[1]
Dosage: 2.5 mg/kg; 25 mg/kg; 50 mg/kg; 100 mg/kg
Administration: i.g.; single dose
Result: Reduced residual plasma MPO activity by 24% at 2.5 mg/kg, 62% at 25 mg/kg, 74% at 50 mg/kg, and 86% at 100 mg/kg, measured 5 hours post-dose.
Caused dose-dependent inhibition of 3-chlorotyrosine accumulation in peritoneal exudate.
Achieved an apparent in vivo IC50 of 1.4 μM for inhibition of plasma MPO activity.
分子量

321.18

Formula

C13H13BrN4O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Aminopyridine 2 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aminopyridine 22411643-58-6Aminopyridine2Aminopyridine-2Glutathione Peroxidaseplasmavasomotor dysfunctionperitonitischronic inflammatory diseasethyroid peroxidasemouse peritonitis modelhuman MPOmyeloperoxidaseInhibitorinhibitorinhibit

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