2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. Amlodipine orotate

Amlodipine orotate 是一种抗心绞痛剂和具有口服活性二氢吡啶钙通道阻滞剂，通过阻断电压依赖性的 L 型钙通道，从而抑制钙离子内流。Amlodipine orotate 可用于高血压和癌症的研究。

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CAS No. : 914941-70-1

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Amlodipine orotate 的其他形式现货产品:

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Amlodipine orotate 相关抗体

Top Publications Citing Use of Products

    Amlodipine orotate purchased from MCE. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317.  [Abstract]

    A CCK-8 assay was used to detect the effect of AMs on the proliferation of Ishikawa cells. The results showed that the half-maximal inhibitory concentration (IC50) of Amlodipine (AM) against Ishikawa cells (at 72 h) was 12.36 μM.

    Amlodipine orotate purchased from MCE. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317.  [Abstract]

    Cell apoptosis rate was detected by flow cytometry using Annexin-V/PI staining. The results showed that the apoptotic rate of the Amlodipine (AM) (15 μM; 12 h)-treated Ishikawa cells was 16.8%, which was 2.16-fold higher than that in cells treated with DMSO.

    Amlodipine orotate purchased from MCE. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317.  [Abstract]

    EdU staining showing the effect of Amlodipine (AM) (15 μM; 48 h) on Ishikawa cells. The EdU staining assay revealed that the EdU-positive rate of the AM-treated Ishikawa cells was significantly reduced compared with that of the control group.

    Amlodipine orotate purchased from MCE. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317.  [Abstract]

    Amlodipine (AM) (15 or 20 mg/kg; i.p.; every other day for two weeks) inhibited tumor growth in a dose-dependent manner in BALB/c nude mice bearing subcutaneous xenografts established from Ishikawa cells.

    Amlodipine orotate purchased from MCE. Usage Cited in: Food Chem Toxicol. 2025 Feb 10:115317.  [Abstract]

    H&E and PCNA staining of sections from mice treated with Amlodipine (AM) (15 or 20 mg/kg; i.p.; every other day for two weeks).

    Amlodipine orotate purchased from MCE. Usage Cited in: Exp Mol Med. 2021 Apr;53(4):572-590.  [Abstract]

    Rat GMCs pretreated with the calcium channel blocker Amlodipine (10μM), inhibitors of PKC (Go6983; 10μM), c-Raf (AZ628, 10μM) and MEK1/2 (U0126, 10μM) for 30min were stimulated with sublytic C5b-9 for 4 0min or 2h. The intracellular calcium was determined by Fluo-4 AM. The results showed that Amlodipine effectively blocked the rise in intracellular calcium levels in rat GMCs induced by 40 min of sublytic C5b-9 stimulation.

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    N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Amlodipine orotate, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine orotate can be used for the research of high blood pressure and cancer[1][2][3][4].

    体外研究
    (In Vitro)

    Amlodipine (30 μM，预处理 1 小时) orotate 能显著抑制尿苷 5′-三磷酸 (UTP) 诱导的 A431 细胞内钙离子浓度 ([Ca2+]i)升高[3]。
    Amlodipine (30 μM) orotate 可抑制毒胡萝卜素 (Thapsigargin) 在 Fluo-3 负载细胞中诱发的钙库操纵性钙内流 (SOCE)[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Amlodipine orotate 相关抗体:
    体内研究
    (In Vivo)

    Amlodipine (5 mg/kg/天，皮下给药，持续 2 周) orotate 可显著降低血管平滑肌细胞 ATP2B1 基因敲除 (KO) 小鼠的收缩压[4]。
    Amlodipine (10 mg/kg，腹腔注射，每日 1 次，持续 20 天) orotate 能显著延缓肿瘤生长，并延长 A431 荷瘤小鼠的生存期[3]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: ATP2B1loxP/loxP mice[4]
    Dosage: 5 mg/kg/day
    Administration: Subcutaneously implanted osmotic pump for 2 weeks
    Result: Significantly decreased the blood pressure.
    分子量

    564.97

    Formula

    C25H29ClN4O9
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Amlodipine orotate 相关分类

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Amlodipine914941-70-1Calcium ChannelCa2+ channelsCa channelsoraldihydropyridineantianginalhypertensionInhibitorinhibitorinhibit

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