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  3. Drug Derivative
  4. AMP-404

AMP-404 是一种 Imexon (HY-15385) 衍生的抗肿瘤剂，兼具细胞毒素和生长抑制剂的双重功能。AMP-404 对包括骨髓瘤、乳腺癌、黑色素瘤、卵巢癌及肉瘤在内的多种敏感型、耐药型及原代人肿瘤细胞均表现出显著的细胞毒作用。AMP-404 在体内有效抑制大鼠 PIE 2-3 肉瘤的生长，具有显著体内效力。

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AMP-404

AMP-404 Chemical Structure

CAS No. : 55275-64-4

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AMP-404 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AMP-404 is an Imexon (HY-15385)-derived antitumor agent with dual functions as a cytotoxin and growth inhibitor. AMP-404 exerts significant cytotoxic effects against various sensitive, drug-resistant and primary human tumor cells, including myeloma, breast cancer, melanoma, ovarian cancer and sarcoma cells. AMP-404 effectively inhibits the growth of rat PIE 2-3 sarcoma in vivo and exhibits remarkable in vivo efficacy[1][2].

体外研究
(In Vitro)

AMP-404 (compound 13) 可强效抑制多种已建系的人源和鼠源肿瘤细胞系的生长，包括耐药突变株，其 IC50 值范围为 1.2 μM (鼠敏感型 L1210 白血病) 至 12 μM (人多药耐药 WiDr 结肠癌)[1]。
AMP-404 (0.2-2.0 μM; 24 h) 可抑制多种新鲜人源肿瘤细胞的集落生长，对骨髓瘤、胃癌和肉瘤的活性最强[1]。
AMP-404 的抗骨髓瘤效力 log (1/C) 值为 5.27，该值符合亲脂性与人敏感型多发性骨髓瘤细胞毒性之间的正相关性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AMP-404 相关抗体:
体内研究
(In Vivo)

AMP-404 (compound 13) 对 Wistar 大鼠的 PIE 2-3 肉瘤具有抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

187.20

Formula

C10H9N3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AMP-404 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMP-40455275-64-4AMP404AMP 404Drug DerivativeDrug derivativebreast carcinomacolon carcinomasarcoma cellsovarian carcinomamelanomaPIE 2-3 sarcomaL1210 leukemiaWistar ratsmyelomamultiple myelomaInhibitorinhibitorinhibit

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