2. Anti-infection Metabolic Enzyme/Protease
  3. Parasite Mitochondrial Metabolism
  4. Amquinate

Amquinate 是一种抗球虫剂和细胞色素 b 抑制剂。Amquinate 可阻断线粒体中细胞色素 b 附近由细胞色素 e 介导的电子传递，作用于辅酶 Q 下游，且不影响琥珀酸脱氢酶或 NADH 脱氢酶。Amquinate 可抑制 Eimeria tenella 中由琥珀酸、以及苹果酸加丙酮酸支持的线粒体呼吸，但不影响由 L-抗坏血酸支持的呼吸，也不影响鸡肝线粒体中的任何线粒体呼吸。Amquinate 对野生型 Eimeria tenella 表现出选择性抗球虫活性。Amquinate 可用于球虫病 (Eimeria tenella 感染) 的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Amquinate

Amquinate Chemical Structure

CAS No. : 17230-85-2

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Amquinate 相关抗体

Top Publications Citing Use of Products

查看 Parasite 亚型特异性产品:

查看所有亚型
Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Amquinate is a coccidiostat and a cytochrome b inhibitor. Amquinate blocks cytochrome-mediated electron transport near cytochrome b in mitochondria, acting downstream of coenzyme Q without affecting succinate dehydrogenase or NADH dehydrogenase. Amquinate inhibits succinate- and malate plus pyruvate-supported mitochondrial respiration in Eimeria tenella and does not affect L-ascorbate-supported respiration or any mitochondrial respiration in chicken liver mitochondria. Amquinate exhibits selective anticoccidial activity against wild-type Eimeria tenella. Amquinate can be used for the research of coccidiosis (Eimeria tenella infection)[1].

体外研究
(In Vitro)

Amquinate 可强效抑制野生型 Eimeria tenella 线粒体中由琥珀酸和 NADH 供能的呼吸作用，其 IC50 为 1×10-8 M；浓度 >1×10-3 M 时，对鸡肝线粒体呼吸无影响；且在 1×10-4 M 浓度下，不会抑制琥珀酸脱氢酶-辅酶 Q 还原酶或 NADH 脱氢酶-辅酶 Q 还原酶的活性[1]。
Amquinate 对耐 Amquinate 的 Eimeria tenella 突变株线粒体的敏感性降低 100 倍，其对琥珀酸支持的呼吸作用的 IC50 为 1×10-6 M[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Amquinate 相关抗体:
体内研究
(In Vivo)

Amquinate (30 ppm；饲料给药) 在鸡体内对野生型 Eimeria tenella 表现出抗球虫活性，其最低有效日粮剂量为 30 ppm[1]。
Amquinate (2000 ppm；饲料给药) 相较于野生型寄生虫，在抗鸡的耐 Amquinate 的 Eimeria tenella 突变株感染时展现抗球虫活性所需的最低有效日粮剂量 (2000 ppm) 要高 66.7 倍[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eimeria tenella[1]
Dosage: 30 ppm
Administration: dietary
Result: Was identified as the minimal effective dose against wild-type Eimeria tenella infection.
Animal Model: Amquinate-resistant Eimeria tenella mutant[1]
Dosage: 2000 ppm
Administration: dietary
Result: Was identified as the minimal effective dose against amquinate-resistant Eimeria tenella mutant infection; Represented a 66.7-fold increase in the minimal effective dose compared to wild-type Eimeria tenella.
分子量

316.40

Formula

C18H24N2O3
CAS 号
中文名称

胺喹甲酯
结构分类
初始来源

Mitochondria from Eimeria tenella
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Amquinate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Amquinate17230-85-2胺喹甲酯ParasiteMitochondrial MetabolismcoccidiosisNADH dehydrogenaseEimeria tenellachicken liver mitochondriamitochondriasuccinate dehydrogenasecoenzyme Qcytochrome banticoccidial activityrespiration inhibitorInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Amquinate
目录号：
HY-114625
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z