2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. AMX12006

AMX12006 是一种有效的、选择性的和具有口服活性的 EP4 拮抗剂，IC50 值为 4.3 nM。AMX12006 具有细胞毒性和抗肿瘤活性。

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AMX12006

AMX12006 Chemical Structure

CAS No. : 2639775-01-0

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规格 价格 是否有货 数量
1 mg ￥1731
In-stock
5 mg ￥5192
In-stock
10 mg 现货 询价
50 mg   询价  
100 mg   询价  

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Customer Review

AMX12006 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AMX12006 is a potent, selective and orally active EP4 antagonist with an IC50 value of 4.3 nM. AMX12006 shows cytotoxic and antitumor activity[1].

IC50 & Target[1]

hEP4

4.3 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
4T1 IC50
79.47 μM
Compound: 36; AMX12006
Cytotoxicity against mouse 4T1 cells assessed as inhibition of cell growth measured after 72 hrs by Cell-titer glo assay
Cytotoxicity against mouse 4T1 cells assessed as inhibition of cell growth measured after 72 hrs by Cell-titer glo assay
[PMID: 37312837]
CT26.WT IC50
41.39 μM
Compound: 36; AMX12006
Cytotoxicity against mouse CT26.WT cells assessed as inhibition of cell growth measured after 72 hrs by Cell-titer glo assay
Cytotoxicity against mouse CT26.WT cells assessed as inhibition of cell growth measured after 72 hrs by Cell-titer glo assay
[PMID: 37312837]
MCF7 IC50
46.73 μM
Compound: 36; AMX12006
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by Cell-titer glo assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth measured after 72 hrs by Cell-titer glo assay
[PMID: 37312837]
体外研究
(In Vitro)

AMX12006 (0-100 µM) 具有细胞毒性，对 MCF-7、4T1、HCA-7、CT-26 WT、LLC 细胞的IC50 值分别为 46.73、79.47、>100、41.39、>100 µM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AMX12006 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: MCF-7, 4T1, HCA-7, CT-26 WT, LLC cells
Concentration: 0-100 µM
Incubation Time:
Result: Showed cytotoxic with IC50s of 46.73, 79.47, >100, 41.39, >100 µM for MCF-7, 4T1, HCA-7, CT-26 WT, LLC cells, respectively.
体内研究
(In Vivo)

AMX12006 (75、150 mg/kg；口服；每天一次，持续 11 天) 显示出剂量依赖性的抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

481.47

Formula

C26H22F3N3O3
CAS 号
性状

固体

颜色

White to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

DMF 中的溶解度 : 20 mg/mL (41.54 mM; 超声加热助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0770 mL 10.3849 mL 20.7697 mL
5 mM 0.4154 mL 2.0770 mL 4.1539 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.9%

COA (269 KB)

产品使用指南 (1538 KB)
参考文献

AMX12006 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 2.0770 mL 10.3849 mL 20.7697 mL 51.9243 mL
5 mM 0.4154 mL 2.0770 mL 4.1539 mL 10.3849 mL
10 mM 0.2077 mL 1.0385 mL 2.0770 mL 5.1924 mL
15 mM 0.1385 mL 0.6923 mL 1.3846 mL 3.4616 mL
20 mM 0.1038 mL 0.5192 mL 1.0385 mL 2.5962 mL
25 mM 0.0831 mL 0.4154 mL 0.8308 mL 2.0770 mL
30 mM 0.0692 mL 0.3462 mL 0.6923 mL 1.7308 mL
40 mM 0.0519 mL 0.2596 mL 0.5192 mL 1.2981 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMX120062639775-01-0AMX 12006AMX-12006Prostaglandin Receptororally activecytotoxicantitumorCT-26 cellsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-149290
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