2. Others Anti-infection NF-κB Immunology/Inflammation
  3. Drug Derivative Bacterial NF-κB NO Synthase
  4. Anabsinthin

Anabsinthin 是一种倍半萜内酯二聚体。Anabsinthin 可存在于 Artemisia absinthium L. (苦艾) 中。Anabsinthin 可调控细胞内钙水平，介导抗炎与抗氧化作用。Anabsinthin 可抑制佛波醇 12-肉豆蔻酸酯 13-乙酸酯 (HY-18739) 诱导的超氧阴离子生成、iNOS 和 MUC5AC 蛋白表达上调，以及 IL-1β 转录上调。Anabsinthin 可用于柑橘溃疡病的相关研究。

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Anabsinthin

Anabsinthin Chemical Structure

CAS No. : 6903-12-4

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Anabsinthin 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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nNOS iNOS eNOS

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anabsinthin is a dimeric sesquiterpene lactone. Anabsinthin can be found in Artemisia absinthium L. (wormwood). Anabsinthin modulates intracellular calcium levels, mediates anti-inflammatory and antioxidant effects. Anabsinthin inhibits Phorbol 12-myristate 13-acetate (HY-18739)-induced superoxide anion production, increased iNOS and MUC5AC protein expression, and IL-1β transcription upregulation. Anabsinthin can be used for the research of citrus canker[1][2][3].

IC50 & Target[1]

iNOS

 

体外研究
(In Vitro)

Anabsinthin (1 mM) 可提高 BEAS-2B 细胞中的胞质钙水平，且该活性不依赖于 hTAS2R46[1]。
Anabsinthin (1, 10 μM; 1 h) 可抑制 BEAS-2B 细胞中 PMA 诱导的超氧阴离子生成，且该活性由 hTAS2R46 介导[1]。
Anabsinthin (1, 10 μM; 18 h) 可抑制 BEAS-2B 细胞中 PMA 诱导的 iNOS 蛋白表达 (但不抑制其 mRNA 表达)、MUC5AC 蛋白表达及 IL-1β mRNA 表达，且其对 IL-1β mRNA 表达的抑制活性不依赖 hTAS2R46 介导[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anabsinthin 相关抗体:

Real Time qPCR[1]

Cell Line: human bronchial epithelial BEAS-2B cells
Concentration: 1, 10 μM
Incubation Time: 18 h
Result: Significantly prevented PMA-induced up-regulation of IL-1β transcription.
Did not show reverted inhibitory effect when co-treated with 1 μM of the hTAS2R46 antagonist 3β-hydroxydihydrocostunolide.
分子量

496.64

Formula

C30H40O6
CAS 号
中文名称

安洋艾素
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anabsinthin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anabsinthin6903-12-4安洋艾素Drug DerivativeBacterialNF-κBNO SynthaseDrug derivativeNuclear factor-κBNuclear factor-kappaBNitric oxide synthasesNOSCPBPIL-1βhTAS2R46PBPBEAS-2B cellsiNOScitrus cankerXanthomonas citriArtemisia absinthiumMUC5ACInhibitorinhibitorinhibit

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