2. Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease
  3. GABA Receptor Endogenous Metabolite
  4. Androst-16-en-3-ol

Androst-16-en-3-ol 是一种公猪的一种信息素，能引发发情母猪的交配反应，也存在于人类尿液、血浆、唾液和汗液中。Androst-16-en-3-ol 是一种内源性神经类固醇，可作为 GABAA 受体 (GABAA receptor) 正性调节剂，在小鼠中可产生抗焦虑、抗抑郁和抗惊厥活性。

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Androst-16-en-3-ol

Androst-16-en-3-ol Chemical Structure

CAS No. : 7148-51-8

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Androst-16-en-3-ol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Androst-16-en-3-ol is a pheromone derived from boars that triggers mating responses in estrous sows. It also exists in human urine, plasma, saliva and sweat. As an endogenous neurosteroid, Androst-16-en-3-ol acts as a positive allosteric modulator of GABAA receptors (GABAA receptor) and exerts anxiolytic, antidepressant and anticonvulsant activities in mice.
体外研究
(In Vitro)

Androstenol 可正向调控对小鼠培养小脑颗粒细胞和小鼠小脑切片中的 GABAA受体，其 EC50 分别为 0.4 和 1.4 μM，能够以浓度依赖的方式增强 GABA 激活的电流[1]。
Androstenol (0.1-300 μM) 在 0.1-1 μM 浓度下可增强转染 α1β2γ2 或 α2β2γ2 亚基的 HEK 293 细胞中的 GABAA 受体活性，在 10-300 μM 浓度下则可直接激活这些受体[1]。
Androstenol 可延长小鼠培养小脑颗粒细胞中自发性抑制性突触后电流的持续时间[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Androst-16-en-3-ol 相关抗体:
体内研究
(In Vivo)

Androst-16-en-3-ol (10-100 mg/kg；腹腔注射；单次给药) 对小鼠表现出类抗焦虑作用[1]。
Androst-16-en-3-ol (5-10 mg/kg；腹腔注射；单次给药) 可在强迫游泳试验中使小鼠表现出类抗抑郁作用[1]。
Androst-16-en-3-ol (10-100 mg/kg；腹腔注射；单次给药) 在小鼠中具有抗惊厥活性[1]。
Androst-16-en-3-ol (100-300 mg/kg；腹腔注射；单次给药) 在高剂量下会导致小鼠出现运动障碍，其 TD50 为 181 mg/kg[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NIH Swiss (male, 25-30 g)[1]
Dosage: 10, 30, 50, 100 mg/kg
Administration: i.p.; single dose immediately before testing
Result: Significantly increased the area-under-the-curve for percent time spent in the center of the arena at 30 and 50 mg/kg.
Reduced horizontal activity at 100 mg/kg, making center time values unmeaningful.
Animal Model: NIH Swiss (male, 25-30 g)[1]
Dosage: 10, 30, 50 mg/kg
Administration: i.p.; single dose 15 minutes before testing
Result: Caused a dose-dependent reduction in latency to first open arm entry, increase in number of open arm entries, and increase in percent time spent in open arms; observed significant effects at doses of 10-50 mg/kg depending on the measure.
Animal Model: NIH Swiss (male, 25-30 g)[1]
Dosage: 5, 10, 30 mg/kg
Administration: i.p.; single dose 15 minutes before testing
Result: Reduced immobility times compared with vehicle at 5 and 10 mg/kg; showed no activity at 30 mg/kg.
Animal Model: NIH Swiss (male, 25-30 g)[1]
Dosage: 10, 30, 100 mg/kg
Administration: i.p.; single dose 15 minutes before seizure induction
Result: Conferred dose-dependent protection against seizures in both pentylenetetrazol and 6 Hz electroshock models; reached ED50 values of 21.9 mg/kg (6 Hz model) and 48.9 mg/kg (pentylenetetrazol model).
Animal Model: NIH Swiss (male, 25-30 g)[1]
Dosage: 100, 200, 300 mg/kg
Administration: i.p.; single dose 15 minutes before testing
Result: Caused no impairment at 100 mg/kg; impaired 4/6 mice at 200 mg/kg and 5/6 at 300 mg/kg; reached a TD50 value of 181 mg/kg.
分子量

274.44

Formula

C19H30O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Androst-16-en-3-ol 相关分类

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  • 稀释计算器

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Keywords:

Androst-16-en-3-ol7148-51-83β-AndrostenolGABA ReceptorEndogenous MetaboliteGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptormouseHEK 293 cellscerebellar granule cell GABAA receptorsα1β2γ2 subtypeseizure disordersanxietydepression-like behaviorGABAA receptorα2β2γ2 subtypeblood-brain barrierInhibitorinhibitorinhibit

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