2. Anti-infection Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Cell Cycle/DNA Damage
  3. Bacterial Reactive Oxygen Species (ROS) Lactate Dehydrogenase DNA/RNA Synthesis
  4. Antibacterial agent 330

Antibacterial agent 330 是一种抗菌 (antibacterial) 剂。Antibacterial agent 330 可诱导活性氧 (ROS) 积累，通过嵌入作用形成 DNA 超分子复合物以阻断 DNA 复制，并抑制 LDH 来干扰代谢，进而促使细菌细胞破裂，引发胞内物质泄漏，最终导致细菌死亡。Antibacterial agent 330 在大蜡螟幼虫和小鼠伤口感染模型中均表现出抗菌活性并促进伤口愈合。Antibacterial agent 330 可用于细菌感染的研究。

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Antibacterial agent 330

Antibacterial agent 330 Chemical Structure

CAS No. : 3031427-16-1

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Antibacterial agent 330 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antibacterial agent 330 is an antibacterial agent. Antibacterial agent 330 triggers ROS accumulation, forms DNA supramolecular complex by intercalation to block DNA replication and inhibits LDH to
disturb metabolism, and further prompts bacterial cell rupture to induce the leakage of intracellular content, ultimately causing bacterial death. Antibacterial agent 330 displays antibacterial activity and promotes wound healing in both G. Mellonella larval and murine wound infection models. Antibacterial agent 330 can be used for the research of bacterial infections[1].

体外研究
(In Vitro)

Antibacterial agent 330 (Compound I-10b) 可强效抑制多种革兰氏阳性菌和革兰氏阴性菌菌株的生长 (MICs =
0.0007-0.0026 mM)，对粪肠球菌的最低 MIC 为 0.0003 mM，还可在低浓度下抑制临床分离的粪肠球菌菌株[1]。
Antibacterial agent 330 (4×-8× MIC; up to 8 h) 对金黄色葡萄球菌 25923 和粪肠球菌表现出浓度依赖性杀菌活性，在 8× MIC 条件下 6 小时内即可观察到 CFU 的显著降低[1]。
Antibacterial agent 330 (14 days) 对 Staphylococcus aureus 25923 和 Enterococcus faecalis 诱导细菌耐药性的潜力较低，且可在低浓度下强效抑制磺胺甲恶唑耐药菌株 (0.0007-0.0055 mM)[1]。
Antibacterial agent 330 (32×-64× MIC; 4 h) 表现出可忽略的溶血毒性[1]。
Antibacterial agent 330 (5-40 μg/mL) 对人正常 LO2 肝细胞和 Beas-2b 肺上皮细胞的细胞毒性无显著性[1]。
Antibacterial agent 330 (0.5×-16× MIC) 可以浓度依赖的方式有效抑制并清除金黄色葡萄球菌 25923 和粪肠球菌的生物膜，在 16× MIC 时对金黄色葡萄球菌 25923 生物膜的清除率超过 40%[1]。
Antibacterial agent 330 (1×-16× MIC) 可提高金黄色葡萄球菌 25923 和粪肠球菌的细胞膜通透性[1]。
Antibacterial agent 330 (0.5×-8× MIC) 可诱导金黄色葡萄球菌 25923 和粪肠球菌发生浓度依赖性的蛋白泄漏，表明其可造成细菌膜损伤[1]。
Antibacterial agent 330 (0.5×-16× MIC) 可在金黄色葡萄球菌 25923 和粪肠球菌中引发浓度依赖性的细胞内 ROS 积累[1]。
Antibacterial agent 330 (4×-16× MIC) 可抑制金黄色葡萄球菌 25923 及粪肠球菌的 LDH 活性，在 16× MIC 时抑制率约为 45%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 330 相关抗体:
体内研究
(In Vivo)

Antibacterial agent 330 (Compound I-10b) (0.007-0.014 mM；注射；单次给药) 对大蜡螟幼虫体内的金黄色葡萄球菌 (S. aureus 25923) 表现出强效的抗菌活性，0.007 mM 剂量组的 8 天存活率达 90%，0.014 mM 剂量组则维持近乎完全的存活率[1]。
Antibacterial agent 330 (4× MIC；局部给药；每日 1 次；共 6 天) 可在小鼠伤口感染模型中有效促进伤口愈合并降低 S. aureus 25923 的细菌载量，同时不会影响小鼠的正常体重增长[1]。
Antibacterial agent 330 (5 mg/kg/天；每日给药；连续 3 天) 在昆明小鼠中表现出良好的体内生物安全性，主要脏器未观察到组织病理学损伤[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: S. aureus 25923-infected in Galleria mellonella larvae[1]
Dosage: 0.007 mM (5× MIC); 0.014 mM (10× MIC)
Administration: injection; single dose
Result: Achieved a 90% survival rate at 8 days post-infection (0.007 mM dose).
Maintained a near-100% survival rate over the 8-day observation period (0.014 mM dose).
Showed low in vivo toxicity, with survival rates comparable to saline controls.
Animal Model: S. aureus 25,923-infected mice wound models (18-22 g, 3-8 weeks of age)[1]
Dosage: 4× MIC
Administration: topical; once daily; 6 days
Result: Resulted in a significantly lower residual bacterial load at the wound site compared to PBS and norfloxacin control groups by day 6 post-treatment.
Accelerated wound healing compared to the norfloxacin group, with near-complete wound closure observed by day 6.
Supported normal weight gain throughout the treatment period, consistent with positive control groups.
分子量

759.16

Formula

C34H36ClN4O10PS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antibacterial agent 330 相关分类

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Keywords:

Antibacterial agent 3303031427-16-1Antibacterial agent330Antibacterial agent-330BacterialReactive Oxygen Species (ROS)Lactate DehydrogenaseDNA/RNA SynthesisLDHGram-negative bacterial strainsGram-positive bacterial strainsmethicillin-resistant staphylococcus aureushuman serum albuminlactate dehydrogenasestaphylococcus aureus 25,923Enterococcus faecalisbacterial DNAsulfamethoxazole-resistant bacterial strainsreactive oxygen speciesInhibitorinhibitorinhibit

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