2. Anti-infection
  3. Bacterial
  4. Antibacterial agent 331

Antibacterial agent 331 是一种抗菌剂，具有抗生物膜活性。Antibacterial agent 331 对多种革兰氏阳性菌和和革兰氏阴性菌均有活性。Antibacterial agent 331 可在小鼠模型中清除 MRSE 62 并促进感染伤口的修复。Antibacterial agent 331 可用于感染方面的研究。

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Antibacterial agent 331

Antibacterial agent 331 Chemical Structure

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Antibacterial agent 331 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antibacterial agent 331 is an antibacterial agent with anti-biofilm activity. Antibacterial agent 331 exhibits activity against a variety of Gram-positive and Gram-negative bacteria. Antibacterial agent 331 eliminates MRSE 62 and promotes the repair of infected wounds in mouse models. Antibacterial agent 331 can be used for research on infections[1].

体外研究
(In Vitro)

Antibacterial agent 331 (compound A4) (24 h) 可强效抑制标准革兰氏阳性菌 (单核细胞增生李斯特菌 CMCC54004、金黄色葡萄球菌 ATCC29213、粪肠球菌 BNCC186300) 和革兰氏阴性菌 (鼠伤寒沙门氏菌 SL1344、大肠杆菌 ATCC 25922、铜绿假单胞菌 ATCC 15442) 菌株的生长，其 MIC 值范围为 <0.0625 至 0.25 μg/mL[1]。
Antibacterial agent 331 (24 h) 可强效抑制临床分离的耐药革兰氏阳性菌株 (MRSA 62、L970、L971；MRSE 61、62、63；VRE 11、12、13) 的生长，其 MIC 值范围为 0.125 至 16 μg/mL[1]。
Antibacterial agent 331 (8 μg/mL; 24 h) 可清除 58.1% 的成熟 MRSE 62 生物膜[1]。
Antibacterial agent 331 (24 h) 对 L929 小鼠成纤维细胞表现出低细胞毒性，其 CC50 值>128 μg/mL[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 331 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: L929 mouse fibroblast cells
Concentration: /
Incubation Time: 24 h
Result: Did not significantly reduce L929 cell viability, with a CC50 value >128 μg/mL.
体内研究
(In Vivo)

Antibacterial agent 331 (2× MIC；局部给药；每日 1 次；连续 9 天) 可显著降低感染 MRSE 62 的昆明小鼠的细菌载量，促进感染皮肤伤口愈合，且相关炎症反应极轻微[1]。
Antibacterial agent 331 (50-100 mg/kg；灌胃；每日 1 次；连续 8 天) 在昆明小鼠中耐受性良好，未观察到对体重、器官功能或组织形态的不良影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kunming mice (male, 5-6 weeks of age, 18-22 g for biosafety study; male, 20±2 g for skin infection study)[1]
Dosage: 2× MIC
Administration: local; once daily; 9 days
Result: Reduced MRSE 62 bacterial load by approximately 3.1 log10 relative to controls.
Enhanced wound healing, with a higher wound contraction rate on day 3 compared to controls and reference groups.
Induced minimal inflammatory cell infiltration and near-normal cell morphology in treated tissue, unlike control and ciprofloxacin groups with obvious inflammatory cell infiltration and tissue abnormalities.
分子量

556.61

Formula

C26H29FN6O5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antibacterial agent 331 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 331Antibacterial agent331Antibacterial agent-331BacterialmethicillinStaphylococcus epidermidisListeria monocytogenes CMCC54004MRSE 62Escherichia coli ATCC 25922mouse modelSalmonella typhimurium SL1344Staphylococcus aureus ATCC29213Enterococcus faecalis BNCC186300L929 mouse fibroblast cellsPseudomonas aeruginosa ATCC 15442Inhibitorinhibitorinhibit

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产品名称：
Antibacterial agent 331
目录号：
HY-182056
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