2. Anti-infection
  3. Bacterial
  4. Antibacterial agent 333

Antibacterial agent 333 是 Tryptanthrin (HY-N6607) 的衍生物，是一种抗菌 (antibacterial) 剂，对副溶血性弧菌 (Vibrio parahaemolyticus) (MIC50 = 8 μg/mL) 和溶藻弧菌 (Vibrio alginolyticus) (MIC50 = 16 μg/mL) 均有抗菌活性。Antibacterial agent 333 可抑制生物膜的形成与成熟。Antibacterial agent 333 对耐药性弧菌菌株具有活性。Antibacterial agent 333 对哺乳动物细胞无细胞毒性，且无溶血活性。Antibacterial agent 333 可用于感染相关研究。

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Antibacterial agent 333

Antibacterial agent 333 Chemical Structure

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Antibacterial agent 333 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antibacterial agent 333, Tryptanthrin (HY-N6607) derivative, is a antibacterial agent with antibacterial activity against Vibrio parahaemolyticus (MIC50 = 8 μg/mL) and Vibrio alginolyticus (MIC50 = 16 μg/mL). Antibacterial agent 333 inhibits biofilm formation and maturation. Antibacterial agent 333 exhibits activity against drug-resistant Vibrio strains. Antibacterial agent 333 lacks cytotoxicity toward mammalian cells and has no hemolytic activity. Antibacterial agent 333 can be used for the research of infection[1].

体外研究
(In Vitro)

Antibacterial agent 333 (Compound 7h) 可强效抑制副溶血性弧菌 (Vibrio parahaemolyticus) ATCC 17802 的生长，其 MIC 为 8 μg/mL；同时可抑制溶藻弧菌 (Vibrio alginolyticus) CICC 21664，其 MIC 为 16 μg/mL[1]。
Antibacterial agent 333 (4-32 μg/mL) 可抑制副溶血性弧菌生物膜形成[1]。
Antibacterial agent 333 (8-32 μg/mL; 0-12 h) 对副溶血性弧菌表现出快速的、浓度依赖性杀菌活性，在 16 μg/mL (2×MIC) 条件下 6 h 内即可使细菌数量降至检测限以下，在 32 μg/mL (4×MIC) 条件下该过程仅需 4 h[1]。
Antibacterial agent 333 (16 μg/mL) 会破坏副溶血弧菌的内膜通透性[1]。
Antibacterial agent 333 (4-32 μg/mL; 24-72 h) 对 RAW 264.7 和 HEK 293 T 细胞均无细胞毒性，即使在最高测试浓度下细胞存活率仍保持在 80%以上[1]。
Antibacterial agent 333 (4-32 μg/mL) 对绵羊红细胞无溶血活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 333 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: RAW 264.7, HEK 293 T
Concentration: 4 μg/mL; 8 μg/mL; 16 μg/mL; 32 μg/mL
Incubation Time: 24 h; 48 h; 72 h
Result: Exhibited no detectable cytotoxicity toward RAW 264.7 cells at 4, 8 μg/mL across 24, 48, 72 h.
Maintained RAW 264.7 cell viability above 80% at 16, 32 μg/mL across all time points.
Exhibited no detectable cytotoxicity toward HEK 293 T cells at 4, 8 μg/mL across 24, 48, 72 h.
Maintained HEK 293 T cell viability above 80% at 16, 32 μg/mL across all time points.
分子量

413.38

Formula

C23H15N3O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antibacterial agent 333 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 333Antibacterial agent333Antibacterial agent-333Bacterialdrug-resistant Vibrio strainssepticemiaVibrio parahaemolyticusVibrio alginolyticusacute hepatopancreatic necrosis diseasebody surface ulcersVibrio parahaemolyticus ATCC 17802mammalian cellsbiofilm formationRAW 264.7Inhibitorinhibitorinhibit

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Antibacterial agent 333
目录号：
HY-182310
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