2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial DNA/RNA Synthesis
  4. Antibacterial agent 338

Antibacterial agent 338 (Compound 65) 是一种抗菌 (Antibacterial) 剂、GyrB 抑制剂，对大肠杆菌 GyrB 的 IC50 为 12.60 nM。Antibacterial agent 338 可结合大肠杆菌 GyrB 的 ATP 结合域，从而抑制 GyrB 的 ATP 酶活性。Antibacterial agent 338 对多重耐试剂革兰氏阴性菌具有广谱抗菌活性。Antibacterial agent 338 可降低中性粒细胞减少小鼠大腿感染模型中的细菌载量。Antibacterial agent 338 可用于鲍曼不动杆菌感染的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Antibacterial agent 338

Antibacterial agent 338 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Antibacterial agent 338 相关抗体

Top Publications Citing Use of Products

查看 DNA/RNA Synthesis 亚型特异性产品:

查看所有亚型
RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antibacterial agent 338 (Compound 65) is an antibacterial agent and GyrB inhibitor, with an IC50 of 12.60 nM against GyrB from *E. coli*. Antibacterial agent 338 binds to the ATP-binding domain of *E. coli* GyrB, thereby inhibiting the ATPase activity of GyrB. Antibacterial agent 338 exhibits broad-spectrum antibacterial activity against multidrug-resistant Gram-negative bacteria. Antibacterial agent 338 reduces bacterial load in a neutropenic mouse thigh infection model. Antibacterial agent 338 can be used for the research of *Acinetobacter baumannii* infection[1].

体外研究
(In Vitro)

Antibacterial agent 338 (0.038-10000 nM; 60 min) 可强效抑制大肠杆菌 (E. coli) DNA GyrB ATP 酶活性，其 IC50 为 12.60 nM[1]。
Antibacterial agent 338 (0.03-64 μg/mL; 18-20 h) 对多重耐试剂革兰氏阴性菌具有广谱抗菌活性，其中对多重耐试剂鲍曼不动杆菌 Aba-2024-D2-018 的 MIC 为 0.5 μg/mL[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 338 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route Cmax AUC0-t AUC0-∞ MRT0-∞ T1/2 CL_obs Vss_obs
Rat[1] 5 mg/kg i.v. 2057 ng/mL 961 ng·h/mL 971 ng·h/mL 2.12 h 2.66 h 87.2 mL/min/kg 11.1 L/kg
Mice[1] 20 mg/kg i.v. 35600 ng/mL 16164 16169 0.95 h 0.78 h 20.8 mL/min/kg 1.20 L/kg
体内研究
(In Vivo)

Antibacterial agent 338 (10-20 mg/kg；静脉注射；单次，一日两次) 在中性粒细胞减少小鼠体内对多重耐药鲍曼不动杆菌表现出剂量依赖性的体内效果[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR (half male and half female, 18-22 g, neutropenic via cyclophosphamide injection)[1]
Dosage: 10 mg/kg; 20 mg/kg; 20 mg/kg (two doses 6 hours apart)
Administration: i.v.; single dose; two doses 6 hours apart
Result: Achieved a bacterial burden reduction comparable to positive controls (levofloxacin and compound 9) at 20 mg/kg.
Produced a 2.65-log10 CFU/g reduction in bacterial burden.
Produced a 4.57-log10 CFU/g reduction, corresponding to >99.99% bacterial eradication, with bacterial burden reduced to pretreatment levels.
分子量

489.55

Formula

C25H28FN9O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antibacterial agent 338 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 338Antibacterial agent338Antibacterial agent-338BacterialDNA/RNA SynthesisE. coli GyrBGyrB ATPase activityneutropenic murine thigh infection modelhERG K+ channelCHO-hERG cellsAcinetobacter baumanniiDNA gyrase Bmultidrug-resistant acinetobacter baumannii infectionmultidrug-resistant Gram-negative bacteriaATP-binding domainInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Antibacterial agent 338
目录号：
HY-182936
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z