2. Antibiofilm agent-20

Antibiofilm agent-20 是一种具有口服活性的大肠杆菌 (Escherichia coli) 生物膜抑制剂，且抗菌活性较低 (MIC >128 μg/mL)。Antibiofilm agent-20 具有高亲脂性和低溶解度，导致结肠递送率较低。Antibiofilm agent-20 具有抗炎作用，可降低 IL-17 和 TNF-α 水平。Antibiofilm agent-20 可用于炎症性肠病的研究。

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Antibiofilm agent-20

Antibiofilm agent-20 Chemical Structure

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Antibiofilm agent-20 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antibiofilm agent-20 is an orally active Escherichia coli biofilm inhibitor and show low antibacterial activity (MIC >128 μg/mL). Antibiofilm agent-20 exhibits high lipophilicity and low solubility, resulting in low colon delivery rate. Antibiofilm agent-20 demonstrates anti-inflammatory and reduces IL-17 and TNF-α levels. Antibiofilm agent-20 can be used for the research of inflammatory bowel disease[1].

体外研究
(In Vitro)

Antibiofilm agent-20 (Compound 1) 可强效抑制体外的大肠杆菌生物膜形成，其 IC50 为 5.5 μg/mL，且 MIC > 128 μg/mL[1]。
Antibiofilm agent-20 具有高膜通透性，在 PAMPA 试验中，pH 5.5 时的测定值为 10.3 × 10-6 cm/s，pH 7.4 时为 17.4 × 10-6 cm/s[1]。
Antibiofilm agent-20 (0.5 mg/mL; 30 min) 在小鼠肝微粒体中无代谢稳定性，在蛋白浓度为 0.5 mg/mL 的条件下孵育 30 分钟后，该化合物的剩余量为 0%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antibiofilm agent-20 相关抗体:
药代动力学
(Parmacokinetics)
Species Dose Route C0 T1/2 AUCinf Vdss Tmax Cmax AUCall Bioavailability
Mice[1] 100 mg/kg p.o. / / / / 0.500 h 0.326 μg/mL 1.10 μg·h/mL 15.5 %
Mice[1] 30 mg/kg p.o. / / / / 3.00 h 0.0893 μg/mL 0.297 μg·h/mL 0.682 %
Mice[1] 1 mg/kg i.v. 0.159 μg/mL 1.43 h 0.0724 μg·h/mL 21.1 L/kg / / / /
Mice[1] 1 mg/kg i.v. 15.2 μg/mL 1.26 h 1.45 μg·h/mL 0.106 L/kg / / / /
体内研究
(In Vivo)

Antibiofilm agent-20 (Compound 1) (100 mg/kg；口服；每日一次； 7 天) 在小鼠 DSS (HY-116282C) 诱导的结肠炎模型中表现出抗炎和疾病改善活性，100 mg/kg 口服可显著增加结肠长度并降低促炎细胞因子水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 with DSS-induced colitis model (treatment group n=8)[1]
Dosage: 100 mg/kg
Administration: p.o.
Result: Increased mean colon length.
Reduced mean colon tissue IL-17 levels.
Reduced mean colon tissue TNF-α levels.
分子量

412.01

Formula

C25H34ClN3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antibiofilm agent-20 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibiofilm agent-20Antibiofilm agent20Antibiofilm agent 20Escherichia colibiofilmmouse liver microsomesmouse DSS-induced colitis modelinflammatory bowel diseasepro-inflammatory cytokineInhibitorinhibitorinhibit

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