2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Anticancer agent 312

Anticancer agent 312 是一种异质核核糖核蛋白 A18 (hnRNP A18) 抑制剂，其 IC50 为 2.9 μM。Anticancer agent 312 可结合 hnRNP A18 的 RNA 识别基序，阻断其与同源 RNA 转录本的结合。Anticancer agent 312 可通过阻断 hnRNP A18 介导的 mRNA 翻译，发挥蛋白质合成抑制剂的作用。Anticancer agent 312 可用于黑色素瘤等癌症研究。

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Anticancer agent 312

Anticancer agent 312 Chemical Structure

CAS No. : 664968-32-5

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Anticancer agent 312 相关抗体

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  • 生物活性

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生物活性

Anticancer agent 312 is a heterogeneous nuclear ribonucleoprotein A18 (hnRNP A18) inhibitor with an IC50 of 2.9 μM. Anticancer agent 312 binds to the RNA recognition motif of hnRNP A18 and blocks its binding to homologous RNA transcripts. Anticancer agent 312 acts as a protein synthesis inhibitor by blocking hnRNP A18-mediated mRNA translation. Anticancer agent 312 is applicable to research on cancers such as melanoma[1].

体外研究
(In Vitro)

Anticancer agent 312 (Compound 5) (3 h) 可在 LOX-IM-VI 黑色素瘤细胞中结合并稳定 hnRNP A18，其 EC50 为 23.8 μM[1]。
抗癌剂 312 可破坏 LOX-IM-VI 黑色素瘤细胞中 hnRNP A18 介导的转录本稳定性与翻译过程，降低带有 Trx 3'UTR 报告基因的 CAT 蛋白表达[1]。
Anticancer agent 312 (0-200 μM) 呈剂量依赖性下调 LOX-IM-VI 黑色素瘤细胞中硫氧还蛋白的蛋白表达[1]。
Anticancer agent 312 (0-200 μM) 可呈剂量依赖性下调 PC-3 前列腺癌细胞中的 CTLA-4 蛋白表达[1]。
Anticancer agent 312 (0-150 μM; 24 h) 可选择性降低多种人类癌细胞系的活力，在高浓度下对人正常乳腺上皮细胞具有中等毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 312 相关抗体:
分子量

338.38

Formula

C18H14N2O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 312 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 312664968-32-5Anticancer agent312Anticancer agent-312DNA/RNA SynthesisLOX-IM-VI melanoma cellscolorectal carcinomamelanomaRNA Recognition Motiftriple negative breast cancerhnRNP A18pancreatic cancerPC-3 prostate cancer cellsglioblastomaprostate cancerInhibitorinhibitorinhibit

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