2. Apoptosis
  3. Thymidylate Synthase
  4. Anticancer agent 315

Anticancer agent 315 是一种抗肿瘤剂。Anticancer agent 315 通过与 Lys487 和 Ala498 形成强氢键作用结合到胸苷酸合酶 (thymidylate synthase) 的活性口袋，稳定配体在口袋内的排列。Anticancer agent 315 可抑制肿瘤细胞增殖。Anticancer agent 315 可用于肝癌、乳腺癌的研究。

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Anticancer agent 315

Anticancer agent 315 Chemical Structure

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2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

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Anticancer agent 315 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer agent 315 is an antitumor agent. Anticancer agent 315 binds to the active pocket of thymidylate synthase via forming strong hydrogen bonds with Lys487 and Ala498, stabilizing the arrangement of the ligand within the pocket. Anticancer agent 315 inhibits the proliferation of tumor cells. Anticancer agent 315 can be used for the research of liver cancer and breast cancer[1].

体外研究
(In Vitro)

Anticancer agent 315 (compound 23) 可强效抑制 HepG2 和 MCF-7 癌细胞的活力，同时对 WI-38 和 VERO 正常细胞的毒性较低[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 315 相关抗体:

Cell Viability Assay[1]

Cell Line: HepG2 and MCF-7 cancer cells, WI-38 and VERO normal cells
Concentration: /
Incubation Time: /
Result: Had IC50 values of 15.9 µM and 18.0 µM for HepG2 and MCF-7 cancer cells.
Had IC50 values of 40.2 µM and 45.7 µM for WI-38 and VERO normal cells.
分子量

527.52

Formula

C23H17N11O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer agent 315 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 315Anticancer agent315Anticancer agent-315Thymidylate SynthaseWI-38breast cancerbreast cancer cellsLys487liver cancer cellsthymidylate synthaseMCF-7HepG2Ala498liver cancerInhibitorinhibitorinhibit

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