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  5. Anticancer peptoid 1

Anticancer peptoid 1 (Peptoid 1) 是一种具有抗肿瘤活性的类肽。Anticancer peptoid 1 主要通过损伤质膜发挥细胞毒性作用。Anticancer peptoid 1 对多种癌细胞系具有细胞毒性，包括具有多药耐药性的细胞系。Anticancer peptoid 1 在人乳腺癌异种移植小鼠模型中可抑制肿瘤生长，且无明显急性不良反应。Anticancer peptoid 1 可用于癌症研究，例如乳腺癌和前列腺癌。

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Anticancer peptoid 1

Anticancer peptoid 1 Chemical Structure

CAS No. : 620948-14-3

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Anticancer peptoid 1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anticancer peptoid 1 (Peptoid 1) is a peptoid with antitumor activity. Anticancer peptoid 1 exerts cytotoxicity primarily via plasma membrane damage. Anticancer peptoid 1 exerts cytotoxicity against a broad range of cancer cell lines, including those with multidrug resistance. Anticancer peptoid 1 inhibits tumor growth in a human breast cancer xenotransplantation mouse model without noticeable acute adverse effects. Anticancer peptoid 1 can be used for the research of cancer, such as breast cancer, and prostate cancer[1].

体外研究
(In Vitro)

Anticancer peptoid 1 (72 h) 可强效诱导 MCF-7、LNCaP、OVCAR-3、MRC-5 细胞及原代真皮成纤维细胞产生细胞毒性，处理 72 h 后的 LC50 值分别为 5、5、6、8 和 8 μM[1]。
Anticancer peptoid 1 (0-50 μM; 72 h) 可强效诱导 MCF-7 细胞及多药耐药 MCF-7/TxT50 细胞产生细胞毒性，从而逆转多药耐药性[1]。
Anticancer peptoid 1 (50 μM; 5-60 min) 可在 MCF-7 细胞中诱导快速的质膜损伤，50 μM 浓度在短期处理后可引发约 50% 的 LDH 泄漏[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer peptoid 1 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: MCF-7 (human breast cancer) cells
Concentration: 50 μM (for 50% LDH leakage measurement)
Incubation Time: 5, 30, 60 min
Result: Caused fast LDH release into media; 50 μM peptoid 1 induced ~50% LDH leakage.
Induced rapid plasma membrane damag.
体内研究
(In Vivo)

Anticancer peptoid 1 (1 mg/kg；乳腺脂肪垫注射；每周 3 次；共 12 周) 在人乳腺癌原位异种移植小鼠模型中可显著抑制肿瘤生长，且未观察到急性毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD.Cg-Prkdcscid Il2rgtmlWjl/SzJ (NSG) (4-8 week old female, immunocompromised, orthotopic xenograft model via mammary fat pad injection of human breast cancer cells)[1]
Dosage: 1 mg/kg
Administration: Mammary fat pad injection; three times per week; 12 weeks
Result: Significantly inhibited tumor growth compared to the control peptoid, with a p-value of 0.0014.
Showed no noticeable acute adverse effects.
分子量

1819.32

Formula

C104H139N17O12
CAS 号
Sequence

({NLys}-{Nspe}-{Nspe})4-NH2
Sequence Shortening

({NLys}-{Nspe}-{Nspe})4-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anticancer peptoid 1 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer peptoid 1620948-14-3Peptoid 1Anticancer peptoid1Anticancer peptoid-1Peptoid1Peptoid-1Othersplasma membrane perturbationsMCF-7MRC-5ovarian cancerprostate cancerbreast cancerprimary dermal fibroblast cellsMCF-7/TxT50 cellsOVCAR-3LNCaPInhibitorinhibitorinhibit

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