2. 疾病领域
  3. 感染
  4. 细菌感染
  5. Antifungal agent 153

Antifungal agent 153 是 Blasticidin S (HY-103401A) 的衍生物，是一种抗菌剂。Antifungal agent 153 保留了 Blasticidin S 的抗菌活性，并表现出对多重耐药革兰氏阳性菌的有效抑制，同时显著降低哺乳动物细胞毒性。Antifungal agent 153 可用于细菌感染的相关研究。

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Antifungal agent 153

Antifungal agent 153 Chemical Structure

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Antifungal agent 153 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antifungal agent 153, a derivative of Blasticidin S (HY-103401A), is an antibacterial agent. Antifungal agent 153 retains the antibacterial activity of Blasticidin S, exhibits potent inhibitory effects against multidrug-resistant Gram-positive bacteria, and significantly reduces mammalian cytotoxicity. Antifungal agent 153 can be used in studies related to bacterial infections[1].

体外研究
(In Vitro)

Antifungal agent 153 (Compound 40) 对多种革兰氏阳性病原体表现出显著的抗菌活性，对 MRSA USA300、MRSE 35984、E. faecalis 29212 和 VRE NR-31972，其 MIC 值均为 16 μg/mL；同时对革兰氏阴性 K. pneumoniae 也具有活性，MIC 值为 86 μg/mL[1]。
Antifungal agent 153 对哺乳动物细胞的细胞毒性显著降低，其 CC50 值大于 256 μg/mL[1]。
Antifungal agent 153 (5×-10× MIC; 24 h) 对 MRSA USA300 表现出杀菌活性，可实现细菌的完全清除[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antifungal agent 153 相关抗体:
分子量

745.83

Formula

C36H47N11O7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antifungal agent 153 相关分类

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antifungal agent 153Antifungal agent153Antifungal agent-153vancomycin-resistant enterococciEnterococcus faecalisGram-positive pathogensMRSA USA-300Klebsiella pneumoniaebacterial infectionsbacterial ribosomesGram-negative pathogenseukaryotic ribosomal protein L10mammalian cellsInhibitorinhibitorinhibit

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