2. Anti-infection
  3. Parasite
  4. Antileishmanial agent-17

Antileishmanial agent-17 是一种香豆素杂化化合物，具有抗利什曼原虫作用 (IC50 <0.78 μM)。Antileishmanial agent-17 对正常 VERO 细胞是安全的。Antileishmanial agent-17 抑制叶酸途径。Antileishmanial agent-17 表现出最强效 IC50，对前鞭毛体为 0.40 μM，对无鞭毛体为 0.68 μM。

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Antileishmanial agent-17

Antileishmanial agent-17 Chemical Structure

CAS No. : 2934738-40-4

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Antileishmanial agent-17 相关抗体

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  • 参考文献

生物活性

Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC50 <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC50 value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
Vero CC50
244.3 μM
Compound: 14b
Cytotoxicity against green monkey Vero cells incubated for 72 hrs by crystal violet staining analysis
Cytotoxicity against green monkey Vero cells incubated for 72 hrs by crystal violet staining analysis
[PMID: 37031526]
体外研究
(In Vitro)

Antileishmanial agent-17 (compound 14b) 抑制叶酸途径，对叶酸的抑制率为 82% 和 91%，对亚叶酸的抑制率为 88% 和 91%，分别为 20 μM 和 100 μM[1]。
Antileishmanial agent-17 对非洲绿猴肾细胞 (VERO 细胞) 表现出微弱的细胞毒性，CC50 为 244.3 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antileishmanial agent-17 相关抗体:
分子量

511.61

Formula

C27H37N5O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antileishmanial agent-17 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antileishmanial agent-172934738-40-4Antileishmanial agent17Antileishmanial agent 17ParasiteantileishmanialAfrican green monkey kidney cellsInhibitorinhibitorinhibit

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