2. Epigenetics
  3. Histone Acetyltransferase
  4. Antitumor agent-130

Antitumor agent-130 (Compound 7b) 是一种 p300 组蛋白乙酰转移酶 (HAT) 抑制剂，IC50 为 1.51 μM。Antitumor agent-130 与阿霉素 (HY-15142A) 联用可在体外和体内显著抑制肿瘤生长和侵袭。

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Antitumor agent-130

Antitumor agent-130 Chemical Structure

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Antitumor agent-130 相关抗体

Top Publications Citing Use of Products

查看 Histone Acetyltransferase 亚型特异性产品:

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CBP/p300 GCN5/PCAF TIP60 MOZ/MORF HBO1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-130 (Compound 7b) is a p300 histone acetyltransferases (HAT) inhibitor with an IC50 of 1.51 μM. Antitumor agent-130 combinates with doxorubicin (HY-15142A) can significantly inhibit tumor growth and invasion in vitro and in vivo[1].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
LNCaP IC50
43.745 μM
Compound: 7b
Antiproliferative activity against human LNCaP cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human LNCaP cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 38215590]
MCF-10A IC50
> 50 μM
Compound: 7b
Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF-10A cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 38215590]
MCF7 IC50
17.34 μM
Compound: 7b
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 38215590]
MCF7 IC50
17.34 μM
Compound: 7b
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as inhibition of cell proliferation incubated for 48 hrs by MTT assay
[PMID: 38215590]
PANC-1 IC50
> 50 μM
Compound: 7b
Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Antiproliferative activity against human PANC-1 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 38215590]
分子量

387.81

Formula

C20H18ClNO5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-130 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-130Antitumor agent130Antitumor agent 130Histone AcetyltransferaseHATsHATp300 HAT Inhibitortumor growthtumor invasionInhibitorinhibitorinhibit

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产品名称：
Antitumor agent-130
目录号：
HY-162128
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