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  4. Antitumor agent-212

Antitumor agent-212 是一种 α-外亚甲基硒内酯衍生物，具有显著的选择性抗肿瘤活性。Antitumor agent-212对革兰氏阳性菌 (Gram-positive bacteria) 的最低抑菌浓度 (MIC) 为 128 μg/mL。Antitumor agent-212 在 U87 人胶质瘤异种移植模型中表现出显著的抗肿瘤作用。Antitumor agent-212 可用于胶质瘤、乳腺癌和非小细胞肺癌的研究以及抗菌研究。

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Antitumor agent-212

Antitumor agent-212 Chemical Structure

CAS No. : 3108305-08-1

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Antitumor agent-212 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-212 is a α-exo-methylene-selenolactone derivative with prominent selective antitumor activity. Antitumor agent-212 exhibits an MIC value of 128 μg/mL against Gram-positive bacteria. Antitumor agent-212 exhibits significant antitumor effects in the U87 human glioma xenograft model. Antitumor agent-212 can be used for the study of glioma, breast cancer and non-small cell lung cancer, and antibacterial study[1].

体外研究
(In Vitro)

Antitumor agent-212 (compound 2d) (72 h) 对 U87 细胞 (IC50 = 0.87 μM)、C6 细胞 (IC50 = 0.85 μM)、4T1 细胞 (IC50 = 0.95 μM) 和 A549 细胞 (IC50 = 1.32 μM) 表现出强效的抗增殖活性，对癌细胞的选择性指数为 89.03，显著高于正常 HEK293T 细胞 (IC50 = 77.15 μM)[1]。
Antitumor agent-212 对革兰氏阳性菌金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌 (MRSA) 的最低抑菌浓度 (MIC) 为 128 μg/mL (302.6 μM)，对革兰氏阴性菌铜绿假单胞菌无活性 (MIC > 256 μg/mL) [1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-212 相关抗体:
体内研究
(In Vivo)

Antitumor agent-212 (compound 2d) (30 mg/kg; i.p. and S.C.; once a day; for 15 days) 在雄性 BALB/C 裸鼠的 U87 人胶质瘤异种移植模型中表现出显著的肿瘤生长抑制作用，且无明显毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/C nude mice were implanted with U87 human glioma cells to establish orthotopic xenograft models[1].
Dosage: 30 mg/kg
Administration: Intraperitoneal (IP) and subcutaneous (S.C.) injection; once daily; for 15 days
Result: Significantly inhibited tumor growth from day 12 and reduced tumor volume markedly on day 15 compared to the control group.
No obvious toxicity was observed in mice, with no body weight loss during the experimental period.
分子量

422.81

Formula

C20H22ClNO2Se
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-212 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Antitumor agent-2123108305-08-1Antitumor agent212Antitumor agent 212BacterialAntitumor agentU87 cellsC6 cells4T1 cellsA549 cellsHEK293T cellsmale BALB/C nude miceU87 human glioma xenograft modelorthotopic xenograft modelgliomabreast cancernon-small cell lung cancerantibacterial activityInhibitorinhibitorinhibit

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