2. Antitumor agent-215

Antitumor agent-215 是一种抗肿瘤剂。Antitumor agent-215 可占据胸苷酸合酶 (thymidylate synthase) 的结合口袋，与关键催化残基相互作用。Antitumor agent-215 可诱导癌细胞凋亡 (apoptosis) 和细胞周期阻滞，抑制细胞增殖。Antitumor agent-215 可用于乳腺癌、结直肠癌的研究。

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Antitumor agent-215

Antitumor agent-215 Chemical Structure

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Antitumor agent-215 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-215 is an antitumor agent. Antitumor agent-215 occupies the binding pocket of thymidylate synthase and interacts with key catalytic residues. Antitumor agent-215 induces cancer cell apoptosis and cell cycle arrest, and inhibits cell proliferation. Antitumor agent-215 can be used in the research of breast cancer and colorectal cancer[1].

体外研究
(In Vitro)

Antitumor agent-215 (compound 5c) (48 h) 可强效抑制 MCF-7 乳腺癌细胞和 SW480 结直肠癌细胞的增殖，其针对前者的 IC50 为 4.25 μM，针对后者的 IC50 为 14.30 μM[1]。
Antitumor agent-215 (3-12 μM; 48 h) 以浓度依赖性方式诱导 MCF-7 乳腺癌细胞发生凋亡[1]。
Antitumor agent-215 (3-12 μM; 72 h) 可破坏 MCF-7 乳腺癌细胞中的 DNA 合成，导致细胞周期呈剂量依赖性阻滞，且主要阻滞于 S 期[1]。
Antitumor agent-215 具有良好的预测口服生物利用度和药代动力学特性，但预测存在致突变、致癌及中度 hERG 抑制风险[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-215 相关抗体:

Apoptosis Analysis[1]

Cell Line: human breast cancer MCF-7 cells
Concentration: 3, 6, 12 μM
Incubation Time: 48 h
Result: Induced a concentration-dependent increase in Annexin V-positive cells, rising from 2.86% in untreated controls to 6.30%, 52.10%, and 58.0% at 3 μM, 6 μM, and 12 μM, respectively.

Cell Cycle Analysis[1]

Cell Line: human breast cancer MCF-7 cells
Concentration: 3, 6, 12 μM
Incubation Time: 72 h
Result: Caused a progressive dose-dependent decrease in the G0/G1 cell population and a corresponding increase in cells arrested at the S phase.
Showed minor fluctuations in G2/M phase populations.
分子量

374.46

Formula

C22H18N2O2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-215 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-215Antitumor agent215Antitumor agent 215SW480 colorectal cancer cellsbreast cancercolorectal cancer cellsbreast cancer cellscell cycle arrestthymidylate synthaseMCF-7 breast cancer cellscolorectal cancerapoptosisDNA synthesisInhibitorinhibitorinhibit

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目录号：
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