2. Immunology/Inflammation
  3. Complement System
  4. ANX-M1

ANX-M1 是一种可透过血脑屏障的抗 C1q 抗体。ANX-M1 是抗 C1q 单克隆抗体 ANX005 (HY-P990545) 的小鼠版本。ANX-M1 可减缓光氧化损伤后的视网膜变性进程。ANX-M1 被用于纳米制剂中，以在阿尔茨海默病小鼠模型中评估脑部递送效果。ANX-M1 可用于年龄相关性黄斑变性和阿尔茨海默病的研究 。

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ANX-M1

ANX-M1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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ANX-M1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ANX-M1 is a blood-brain barrier-permeable anti-C1q antibody. ANX-M1 is the mouse version of the anti-C1q monoclonal antibody ANX005 (HY-P990545). ANX-M1 can slow down the progression of retinal degeneration following photo-oxidative damage. ANX-M1 has been incorporated into nanocarriers to evaluate its brain delivery efficacy in a mouse model of Alzheimer's disease. ANX-M1 is applicable for research on age-related macular degeneration and Alzheimer's disease [1][2].

同型

Human IgG1 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target

C1q

 

体内研究
(In Vivo)

ANX-M1 (7.5 μg/μL - 100 mg/kg；玻璃体腔注射；单次给药；腹腔注射；第 0、4、8 天) 可保护光氧化损伤诱导视网膜变性的 C57BL/6J 小鼠免受进行性视网膜变性 (有效方案可减少 TUNEL+ 感光细胞死亡、增加 ONL 厚度、改善 ERG 反应，并使血清补体溶血活性降低 >50%) [1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J (adult, postnatal day 60-90, equal numbers of male and female, photo-oxidative damage-induced retinal degeneration)[1]
Dosage: 7.5 μg/μL (intravitreal post-treatment); 7.5 μg/μL (intravitreal pre-treatment); 100 mg/kg (systemic)
Administration: intravitreal (single dose on day 7 or day 0); intraperitoneal (days 0,4,8)
Result: Significantly reduced TUNEL+ photoreceptor cell death at day 14 compared to IgG control (P < 0.05), significantly increased outer nuclear layer (ONL) thickness (P < 0.05), significantly improved rod a-wave and b-wave electroretinography (ERG) responses (P < 0.05, most pronounced at 1.9 log cd.s/m²), and significantly improved cone ERG responses (P < 0.05) with intravitreal post-treatment; showed no significant differences in TUNEL+ cell count, ONL thickness, IBA1+ cell count, or ERG responses compared to IgG control (P > 0.05) with intravitreal pre-treatment; reduced serum complement hemolytic activity by >50% at day 12 (P < 0.05) but showed no significant differences in TUNEL+ cell count, ONL thickness, IBA1+ cell count, or ERG responses compared to IgG control (P > 0.05) with systemic administration
基因 ID

712  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ANX-M1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ANX-M1Complement SystemTUNEL+ photoreceptor cell deathC57BL/6J miceC1q inhibitorage-related macular degenerationintravitreallyclassical complement pathway activationblood-brain barrierERG responsesB6C3-Tg (APPswe/PSEN1dE9) miceretinal degenerationserum complement hemolytic activityB1R/B2R agonist-functionalized TRIOZAN? nanoparticlesONL thicknessAlzheimer’s diseaseC1qAlzheimer diseasemousephoto-oxidative damageTRIOZAN? NPsanti-C1q monoclonal antibodyInhibitorinhibitorinhibit

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目录号：
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