2. Immunology/Inflammation
  3. Complement System
  4. Tanruprubart

Tanruprubart  (Synonyms: ANX005)

目录号: HY-P990545
一键复制产品信息 纯度: 99.047%
COA 技术支持

Tanruprubart (ANX005) 是一种 C1q 抑制剂和 C1q 耗竭剂。 Tanruprubart 是 CHO 表达的人源抗体，带有 huIgG1 型重链和 huκ 型轻链，其预测的分子量 (MW) 为 145 kDa。Tanruprubart 的同型对照可参考 Human IgG1 kappa, Isotype Control (HY-P99001)。Tanruprubart 对人源的 IC50 为 346 ng/mL，大鼠的 IC50 为 259 ng/mL；对人源的 EC50 为 3.8 ng/mL，大鼠的 EC50 为 5.2 ng/mL，小鼠的 EC50 为 9.9 ng/mL。Tanruprubart 可用于格林-巴利综合征和阿尔茨海默病的研究。

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CAS No. : 2065212-40-8

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1 mg ￥3000
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Tanruprubart 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tanruprubart (ANX005) is a C1q inhibitor and C1q depleter. Tanruprubart is a human antibody expressed in CHO cells, with huIgG1 heavy chains and huκ light chains, and its predicted molecular weight (MW) is 145 kDa. For the isotype control of Tanruprubart, refer to Human IgG1 kappa, Isotype Control (HY-P99001). The IC50 of Tanruprubart is 346 ng/mL for humans and 259 ng/mL for rats; its EC50 is 3.8 ng/mL for humans, 5.2 ng/mL for rats, and 9.9 ng/mL for mice. Tanruprubart is applicable to the research of Guillain-Barré syndrome and Alzheimer's disease[1].

同型

Human IgG1 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target

C1q
体外研究
(In Vitro)

Tanruprubart (Titered concentrations) 与人、食蟹猴、恒河猴、犬、大鼠血清来源的 C1q 具有高度相似的亲和力，与小鼠 C1q 的亲和力较低，且不结合兔 C1q[1]。
Tanruprubart (梯度浓度；孵育 1 小时) 可强效抑制人食蟹猴、恒河猴、犬及大鼠血清中经典补体介导的溶血作用，平均 IC50 约为 350 ng/mL，但对兔血清中的溶血作用无抑制效果[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tanruprubart 相关抗体:
体内研究
(In Vivo)

Tanruprubart (ANX005) (10-200 mg/kg; i.v.; once weekly; 4 weeks) 对 Sprague Dawley 大鼠给药 4 周后，可产生剂量依赖性的血清和脑脊液暴露量，在可检测的试剂水平下完全耗竭血清游离 C1q，且在最高达 200 mg/kg 的剂量下未显示出治疗相关毒性，由此得出其未观察到不良反应水平 (NOAEL) 为 200 mg/kg[1]。
Tanruprubart (ANX005) (10-200 mg/kg; i.v.; single bolus dose; once weekly; 4 weeks) 给食蟹猴 (单次给药或每周给药 1 次、连续 4 周) 给药后，会产生剂量依赖性的血清和脑脊液 (CSF) 暴露量；在可检测的试剂水平下，可完全耗竭游离血清 C1q 并抑制补体介导的溶血作用；在较高剂量下可完全占据脑脊液 C1q；且在最高达 200 mg/kg 的剂量下未观察到与治疗相关的毒性，得出的未观察到不良反应水平 (NOAEL) 为 100 mg/kg[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley rats (male and female, young adult, 8-9 weeks old)[1]
Dosage: 10 mg/kg; 50 mg/kg; 100 mg/kg; 200 mg/kg
Administration: i.v.; once weekly; 4 weeks
Result: Depleted free C1q in rat serum at measurable reagent levels.\nShowed dose-proportional increases in serum Cmax; AUC increased greater than dose-proportionally between lower doses, and dose-proportionally between 100 and 200 mg/kg.\nIncreased mean CSF concentrations in a greater-than-dose-proportional manner, with CSF levels representing 0.1% to 0.2% of serum levels on days 38 and 50 of the GLP study.\nExhibited no treatment-related changes in clinical signs, body weight, food consumption, clinical pathology, gross pathology, organ weight, or histopathology at any dose tested.\nAchieved a no observed adverse effect level (NOAEL) of 200 mg/kg.
Animal Model: Cynomolgus monkeys (male and female, 2-4 years old)[1]
Dosage: 15 mg/kg (single bolus); 100 mg/kg (single bolus); 10 mg/kg (weekly x4); 50 mg/kg (weekly x4); 100 mg/kg (weekly x4); 200 mg/kg (weekly x4)
Administration: i.v.; single bolus dose; once weekly; 4 weeks
Result: Depleted free C1q in monkey serum at measurable reagent levels, with free C1q returning to baseline only when reagent levels dropped below detection.\nInhibited ex vivo complement-mediated hemolysis completely at measurable reagent serum levels, with hemolysis activity returning to baseline when reagent levels declined.\nShowed dose-dependent increases in serum concentrations, with trough levels accumulating over weekly doses in the 50, 100, and 200 mg/kg groups (excluding animals with anti-drug antibody responses).\nIncreased mean CSF concentrations with dose, with CSF levels representing 0.04% to 0.11% of serum levels in the non-GLP study, and 0.02% to 0.13% of serum levels in the GLP study on day 29; these CSF levels fully occupied C1q in the CSF at 100 and 200 mg/kg doses on day 29.\nExhibited no treatment-related changes in clinical signs, body weight, food consumption, clinical pathology, gross pathology, organ weight, histopathology, ophthalmic findings, neurologic exams, vital signs, or electrocardiograms at any dose tested.\nAchieved a no observed adverse effect level (NOAEL) of 200 mg/kg.
Clinical Trial
基因 ID

712  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

145.78 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
组分

Please refer to the lot-specific COA for specific buffer information.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Immobilized C1q Protein (HY-NP0194) can bind ANX005. The EC50 for this effect is 2.56 ng/mL.
纯度 & 产品资料

纯度: 99.047%

COA (267 KB) SDS-PAGE (64 KB) SEC-HPLC (158 KB)

抗体抑制剂使用指南 (624 KB)
参考文献

Tanruprubart 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tanruprubart2065212-40-8ANX005ANX 005ANX-005Complement Systemcynomolgus monkeyclassical complement pathwayratdogC1qmouseblood-brain barrierrhesus monkeyGuillain-Barré syndromeclassical complement cascadeInhibitorinhibitorinhibit

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