2. Neuronal Signaling
  3. Tau Protein
  4. Armanezumab

Armanezumab 是一种病理性 tau 蛋白抑制剂，可特异性结合病理性 tau 蛋白暴露的 N 端结构域 (表位覆盖氨基酸 4-8：PRQEF)。Armanezumab 可用于阿尔茨海默病、额颞叶痴呆及皮克病的相关研究。

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Armanezumab

Armanezumab Chemical Structure

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Armanezumab 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Armanezumab is a pathological tau protein inhibitor that specifically binds to the N-terminal domain exposed by pathological tau protein (epitope covering amino acids 4-8: PRQEF). Armanezumab is applicable to research related to Alzheimer's disease, frontotemporal dementia, and Pick's disease[1].

反应种属

Human
体外研究
(In Vitro)

Armanezumab (3-243 nM) 以高亲和力结合重组人源 0N/4R tau 蛋白，其平衡解离常数为 3.88E-08 M[1]。
Armanezumab (0.02-12.5 μM; 1.5 h) 可特异性靶向 tau2-18 的 PRQEF 表位 (第 4-8 位氨基酸)，其中第 6 位 (谷氨酰胺) 和第 7 位 (谷氨酸) 氨基酸对结合至关重要[1]。
Armanezumab (1 μM; 16 h) 可部分保护人神经母细胞瘤 SH-SY5Y 细胞免受 tau 寡聚体介导的细胞毒性作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Armanezumab 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: SH-SY5Y human neuroblastoma cells
Concentration: 1 μM (Armanezumab pre-incubated with 0.5 μM tau oligomers)
Incubation Time: 16 h (cell incubation with oligomer-Armanezumab mixture)
Result: Restored SH-SY5Y cell viability to 89% compared to 36% viability in cells treated with tau oligomers alone, protecting cells from tau oligomer-mediated cytotoxicity.
体内研究
(In Vivo)

Armanezumab (2 μg；颅内注射；单剂量) 可在给药 5 天后降低 THY-Tau22 tau 转基因小鼠脑内的总病理性 tau 蛋白及多种磷酸化病理性 tau 蛋白亚型[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: THY-Tau22 tau transgenic mice (6-month-old)[1]
Dosage: 2 μg
Administration: intracranial injection (hippocampus and cortex); single dose
Result: Reduced total tau (HT7-stained) and phosphorylated tau species including pThr212, pSer214, pSer396/pSer404 (PHF1-stained), pThr212/pSer214 (AT100-stained), pThr231 (AT180-stained), and pSer202/pThr205 (AT8-stained) in the ipsilateral hemisphere compared to contralateral control IgG-injected hemisphere.
Confirmed neuronal integrity at injection sites via anti-NeuN staining.
基因 ID

4137  [NCBI]

Accession
靶点

Tau
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
组分

Please refer to the lot-specific COA for specific buffer information.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Armanezumab 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ArmanezumabTau ProteinN-terminal domain of pathological tautau transgenic mouseHEK293 cellsAlzheimer's diseaseCHO-DG44 cell lineHEK293T cellsPick's diseasefrontotemporal dementiapathological tauSH-SY5Y human neuroblastoma cellsInhibitorinhibitorinhibit

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