2. Others GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  3. Reference Standards GPR119 TRP Channel
  4. AS1269574 (Standard)

AS1269574 (Standard) 是 AS1269574 (HY-107535) 的分析标准品。本产品用于研究及分析应用。AS1269574 是一种有效的，具有口服活性的 GPR119 激动剂，在表达人 GPR119 的 HEK293 细胞中 EC50 为 2.5 μM。AS1269574 激活 TRPA1 阳离子通道，刺激胰高血糖素样肽-1 (GLP-1) 分泌。AS1269574 仅在高糖条件下特异性诱导胰腺 β 细胞分泌葡萄糖依赖性胰岛素。AS1269574 对 2 型糖尿病研究具有潜力。

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AS1269574 (Standard)

AS1269574 (Standard) Chemical Structure

CAS No. : 330981-72-1

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AS1269574 (Standard) 相关抗体

Top Publications Citing Use of Products

查看 TRP Channel 亚型特异性产品:

查看所有亚型
TRPA1 TRPC3 TRPC4 TRPC5 TRPM8 TRPM2 TRPM3 TRPM4 TRPML1 TRPML2 TRPML3 TRPV1 TRPV2 TRPV3 TRPV4 TRPV6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AS1269574 (Standard) is the analytical standard of AS1269574 (HY-107535). This product is intended for research and analytical applications. AS1269574 is a potent, orally available GPR119 agonist, with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic β-cells only under high-glucose conditions. AS1269574 has the potential for the research of type 2 diabetes[1][2].

分子量

308.17

Formula

C13H14BrN3O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AS1269574 (Standard) 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AS1269574 (Standard)330981-72-1Reference StandardsGPR119TRP ChannelG Protein-Coupled Receptor 119Transient receptor potential channelsglucoseinsulinsecretioncationchannelstype2diabetesInhibitorinhibitorinhibit

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