2. Metabolic Enzyme/Protease Apoptosis
  3. NAMPT Caspase Apoptosis
  4. AS1604498

AS1604498 是一种高特异性的人源 NAMPT 竞争性抑制剂，其 IC50 为 44.4 nM。AS1604498 可在功能上抑制 NAMPT 酶活性，减少烟酰胺单核苷酸的生成，降低细胞内 NAD 水平，激活 caspase 3/7 并诱导癌细胞凋亡 (apoptosis)。AS1604498 可用于慢性粒细胞白血病的相关研究。

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AS1604498

AS1604498 Chemical Structure

CAS No. : 361465-74-9

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AS1604498 相关抗体

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AS1604498 is a highly specific competitive inhibitor of human NAMPT, with an IC50 of 44.4 nM. AS1604498 functionally inhibits NAMPT enzymatic activity, reduces nicotinamide mononucleotide production, decreases intracellular NAD levels, activates caspase 3/7 and induces cancer cell apoptosis. AS1604498 is applicable to research related to chronic myeloid leukemia[1].

体外研究
(In Vitro)

AS1604498 (0.032-10 μM; 48 h) 可抑制人白血病细胞系 THP-1 的生长，其 IC50 为 198 nM，且该作用可被 10 mM Nicotinamide (HY-B0150) 逆转[1]。
AS1604498 (0.032-10 μM; 48 h) 可抑制人慢性粒细胞白血病细胞 K562 的生长，其 IC50 为 673 nM，且该作用可被 10 mM Nicotinamide 逆转[1]。
AS1604498 (10 μM; 48 h) 可在 THP-1 细胞中诱导延迟的 caspase 3/7 活化，且该活化作用可被 10 mM Nicotinamide[1]逆转。
AS1604498 (0.001-10 μM; 5 h) 以剂量依赖的方式降低 K562 细胞内的 NAD 水平，且该效应可被 10 mM Nicotinamide 逆转[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AS1604498 相关抗体:

Cell Proliferation Assay[1]

Cell Line: THP-1 human leukemia cell
Concentration: 0.032, 0.1, 0.32, 1, 3.2, 10 μM
Incubation Time: 48 h
Result: Dose-dependently inhibited THP-1 cell proliferation, with an IC50 of 198 nM (equivalent to 198 nM).
Was completely reversed in growth inhibitory effect by the addition of 10 mM nicotinamide.

Cell Proliferation Assay[1]

Cell Line: K562 human chronic myelogenous leukemia cell
Concentration: 0.032, 0.1, 0.32, 1, 3.2, 10 μM
Incubation Time: 48 h
Result: Dose-dependently inhibited K562 cell proliferation, with an IC50 of 673 nM (equivalent to 673 nM).
Was completely reversed in growth inhibitory effect by the addition of 10 mM nicotinamide.
分子量

319.36

Formula

C19H17N3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AS1604498 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AS1604498361465-74-9AS 1604498AS-1604498NAMPTCaspaseApoptosisNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorNAMPT dimer interface pocketcancer cellsK562 human chronic myelogenous leukemia cellNAMPT enzyme activitycaspase 3/7human NAMPTchronic myelogenous leukemiaTHP-1 human leukemia cellintracellular NAD levelsnicotinamide mononucleotideInhibitorinhibitorinhibit

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