2. MAPK/ERK Pathway Apoptosis
  3. MAP4K Apoptosis
  4. AT-051/43421517

AT-051/43421517 是一种可结合人磷酸甘油酸激酶 1 (hPgk1) 的细胞保护剂和凋亡抑制剂。AT-051/43421517 可保护细胞免受鱼藤酮诱导的细胞死亡，且不会诱导细胞增殖。AT-051/43421517 可用于帕金森病的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

AT-051/43421517

AT-051/43421517 Chemical Structure

CAS No. : 1241957-37-8

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

AT-051/43421517 相关抗体

Top Publications Citing Use of Products

查看 MAP4K 亚型特异性产品:

查看所有亚型
MAP4K2/GCK MAP4K3/GLK MAP4K4/HGK MAP4K5/KHS1 MAP4K6/MINK1 MAP4K7/TNIK MAP4K1/HPK1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AT-051/43421517 is a cytoprotective agent and apoptosis inhibitor that binds to human phosphoglycerate kinase 1 (hPgk1). AT-051/43421517 protects cells from rotenone-induced cell death without inducing cell proliferation. AT-051/43421517 can be used for the research of parkinson’s disease[1].

体外研究
(In Vitro)

AT-051/43421517 可与纯化的人磷酸甘油酸激酶 1 (hPgk1) 结合，ChemScore 为 33.379；它占据与特拉唑嗪相同的结合位点，并与 hPgk1 的关键残基形成特征性疏水相互作用[1]。
AT-051/43421517 (10 μM; 48 h) 可保护 PC12 细胞免受鱼藤酮诱导的细胞死亡，将细胞存活率提升至对照组的 87.97%，且不会诱导细胞增殖[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AT-051/43421517 相关抗体:

Cell Viability Assay[1]

Cell Line: PC12 cells
Concentration: 10 μM (co-incubation with rotenone; incubation alone)
Incubation Time: 48 h (co-incubation with rotenone; incubation alone)
Result: Increased PC12 cell viability to 87.97% of control when co-treated with rotenone, a statistically significant improvement compared to the rotenone-only model group (73.84% of control).
Did not show a statistically significant improvement in cell viability when treated alone, ruling out cell proliferation as a contributor to the observed effect.
分子量

304.39

Formula

C20H20N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AT-051/43421517 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AT-051/434215171241957-37-8MAP4KApoptosisMAPK Kinase Kinase Kinaseterazosinrotenoneparkinson’s diseasehuman phosphoglycerate kinase 1hPgk1PC12 cellsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
AT-051/43421517
目录号：
HY-182811
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z