2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. AT1412

AT1412 是一种可结合 CD9 抗体。AT1412 与四跨膜蛋白 CD9 结合，可通过增强 T 细胞与内皮细胞（HUVEC）的黏附和跨内皮迁移来调节 CD9 功能。AT1412 结合 B-ALL 细胞系而不结合 T-ALL。AT1412 诱导 B-ALL 细胞系的抗体依赖性细胞毒性。AT1412 结合黑色素瘤细胞、B-ALL、胃癌 、结肠癌和胰腺癌细胞 [1] [2]。

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AT1412

AT1412 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
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5 mg   询价  
10 mg   询价  

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Customer Review

AT1412 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AT1412 is a CD9-binding antibody. AT1412 binds to the tetraspanin protein CD9 and modulates CD9 function by enhancing T cell adhesion to endothelial cells (HUVECs) and transendothelial migration. AT1412 binds to B-ALL cell lines but not to T-ALL. AT1412 induces antibody-dependent cellular cytotoxicity in B-ALL cell lines. AT1412 binds to melanoma cells, B-ALL, gastric cancer, colorectal cancer, and pancreatic cancer cells [1] [2].

反应种属

Human
IC50 & Target

CD9

 

体外研究
(In Vitro)

AT1412 与四跨膜蛋白 CD9 结合，可通过增强 T 细胞与内皮细胞（HUVEC）的黏附和跨内皮迁移来调节 CD9 功能[2]。
AT1412 诱导了 B-ALL 细胞系 SUP-B15、MHH-CALL-2 和 CCRF-SB 的抗体依赖性细胞毒性 [1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AT1412 相关抗体:
体内研究
(In Vivo)

AT1412（最高剂量为 10 mg/kg）在非人灵长类动物中具有良好的耐受性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
基因 ID

928  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AT1412 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AT1412AT14-012AT 1412AT-1412Transmembrane GlycoproteinB-ALL blastsantibody dependent cellular cytotoxicityA375-CD9KOCD8 T-cellICAM-1A375 melanomaA375wtADCPB-ALLeffector cellsmelanoma cellsLFA-1CD9human immune system mouse modelsgranulocyticVLA-4lymphocytic populationsmetastatic melanomaT cellstetraspanin CD9endothelial cellscolon cancer cellsADCCmonocyticHIS mouse modelsnivolumabSK-MEL5 melanoma cellsPD-1 resistant SK-MEL5 melanoma modelpancreatic cancer cellsgastric cancer cellsHUVEC cellsantibody-dependent cellular phagocytosisNSG micecd9 positive precursor b-acute lymphoblastic leukemiamacrophageintegrin signalingVCAM-1Inhibitorinhibitorinhibit

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目录号：
HY-P991896
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