2. Immunology/Inflammation Apoptosis
  3. NO Synthase Apoptosis
  4. ATV399

ATV399 是一种诱导型一氧化氮合酶 (iNOS) 抑制剂。ATV399 通过变构抑制 iNOS 二聚化来减少 NO 产生，从而保护大鼠胰岛 β 细胞免受细胞因子诱导的线粒体应激、内质网应激和细胞凋亡 (apoptosis)。ATV399 可用于 1 型糖尿病的相关研究。

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ATV399

ATV399 Chemical Structure

CAS No. : 393834-37-2

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ATV399 相关抗体

Top Publications Citing Use of Products

查看 NO Synthase 亚型特异性产品:

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nNOS iNOS eNOS

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ATV399 is an inducible nitric oxide synthase (iNOS) inhibitor. ATV399 reduces NO production via allosteric inhibition of iNOS dimerization, thereby protecting rat pancreatic islet β-cells from cytokine-induced mitochondrial stress, endoplasmic reticulum stress, and apoptosis. ATV399 can be used in research related to type 1 diabetes[1].

体外研究
(In Vitro)

ATV399 (0.04-5 μM; 48 h) 可抑制细胞因子诱导的活化型半胱天冬酶-9 的激活，其 IC50 为 3.3 μM；同时在经促炎细胞因子和高糖处理的大鼠胰岛素分泌 INS1E 细胞中，该化合物可完全维持细胞活力、保护胰岛素分泌功能，并降低内质网应激水平及促凋亡蛋白表达量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ATV399 相关抗体:

Cell Viability Assay[1]

Cell Line: Rat insulin-producing INS1E cells
Concentration: 0.04, 0.2, 1, 5 μM (24 h pretreatment followed by 24 h co-treatment with cytokines); 5 μM (24 h pretreatment followed by 24 h co-treatment with cytokines and high glucose)
Incubation Time: 24 h (pretreatment) + 24 h (co-treatment with cytokines); 24 h (pretreatment) + 24 h (co-treatment with cytokines and high glucose)
Result: Dose-dependently inhibited cytokine-induced cleaved caspase-9 activation with an IC50 of 3.3 μM.
Fully prevented the 60% reduction in cell viability caused by cytokines at 5 μM.
Restored insulin secretion levels.
Significantly reduced cytokine-induced upregulation of ER stress-related genes including ATF4, ATF6, BiP, CHOP, protein disulfide isomerase, and sXBP1 at 5 μM.
Decreased protein levels of the pro-apoptotic markers CHOP and cleaved caspase-3 at 5 μM.
分子量

465.52

Formula

C24H23N3O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ATV399 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATV399393834-37-2ATV 399ATV-399NO SynthaseApoptosisNitric oxide synthasesNOSendoplasmic reticulum stressrat insulin-producing INS1E cellsinsulin-producing cellsCHOPnitric oxideiNOScleaved caspase-9caspase-3/7CYP3A4inducible NOSInhibitorinhibitorinhibit

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目录号：
HY-119119
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