2. Anti-infection
  3. Bacterial
  4. AW00718

AW00718 是一种猪痢疾短螺旋体 (Brachyspira pilosicoli) 谷氨酸消旋酶 (Bp-MurI) 抑制剂。AW00718 可与 Bp-MurI 的活性位点残基结合，与该酶结合腔内的保守氨基酸形成稳定的氢键和相互作用。AW00718 在体外对猪痢疾短螺旋体具有抗菌 (antibacterial) 和杀菌活性。AW00718 可用于肠道螺旋体病的研究。

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AW00718

AW00718 Chemical Structure

CAS No. : 215778-00-0

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AW00718 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AW00718 is a Brachyspira pilosicoli glutamate racemase (Bp-MurI) inhibitor. AW00718 binds to Bp-MurI active site residues, forming stable hydrogen bonds and interactions with conserved amino acids in the enzyme’s binding cavity. AW00718 exerts antibacterial and bactericidal activity against Brachyspira pilosicoli in vitro. AW00718 can be used for the research of intestinal spirochaetosis[1].

体外研究
(In Vitro)

AW00718 可与同源建模的猪痢疾短螺旋体谷氨酸消旋酶 (Bp-MurI) 形成稳定复合物[1]。
AW00718 (5 days) 可在体外抑制 Brachyspira pilosicoli 菌株 BP2904 的生长，其 MIC50 为 0.25 mM，MIC100 为 0.5 mM[1]。
AW00718 (1 mM; 24 h) 经 24 小时处理并经 Resazurin (HY-118540) 孵育 6 小时后，会对人结膜上皮细胞产生约 20-25% 的细胞毒性；而经 Resazurin 孵育 24 小时后未检测到细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AW00718 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: human Chang conjunctival epithelial cells
Concentration: 1 mM
Incubation Time: 24 h following6 h (Resazurin exposure); 24 h (Resazurin exposure single)
Result: Induced ~20-25% cytotoxicity in human Chang conjunctival epithelial cells after 6 hours of Resazurin exposure.
Caused 0% cytotoxicity after 24 hours of resazurin single exposure.
分子量

385.28

Formula

C17H13BrN4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AW00718 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AW00718215778-00-0AW 00718AW-00718BacterialBrachyspira pilosicoli strain BP2904Bp-MurIBrachyspira pilosicoliCYP isoenzymesBrachyspira pilosicoli glutamate racemaseintestinal spirochaetosisepithelial cellshuman Chang conjunctival epithelial cellsInhibitorinhibitorinhibit

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目录号：
HY-183076
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