2. Others Apoptosis Immunology/Inflammation
  3. Reference Standards TNF Receptor Interleukin Related IFNAR
  4. AX-024 hydrochloride (Standard)

AX-024 hydrochloride (Standard) 是 AX-024 (hydrochloride) (HY-107390A) 的分析标准品。本产品用于研究及分析应用。AX-024 hydrochloride 是一种口服可利用的，首创的 TCR-Nck 相互作用抑制剂，可选择性地抑制 TCR 触发的 T 细胞活化，IC50 值为 1 nM。AX-024 hydrochloride 通过靶向 SH3 结构域调节细胞信号传导。AX-024 hydrochloride 具有低毒、高效、高选择性的特点。AX-024 hydrochloride 有效抑制白细胞介素-6 (IL-6)，肿瘤坏死因子-α (TNFα)，干扰素-γ (IFN-γ)，IL-10 和 IL-17A 的产生。

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AX-024 hydrochloride (Standard)

AX-024 hydrochloride (Standard) Chemical Structure

CAS No. : 1704801-24-0

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AX-024 hydrochloride (Standard) 相关抗体

Top Publications Citing Use of Products

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生物活性

AX-024 hydrochloride (Standard) is the analytical standard of AX-024 (hydrochloride) (HY-107390A). This product is intended for research and analytical applications. AX-024 hydrochloride is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ~1 nM. AX-024 hydrochloride modulates cell signaling by targeting SH3 domains. AX-024 hydrochloride has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.

IC50 & Target

IL-6, TNFα, IFN-γ, IL-10 and IL-17A[1]
分子量

375.86

Formula

C21H23ClFNO2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AX-024 hydrochloride (Standard) 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AX-024 hydrochloride (Standard)1704801-24-0Reference StandardsTNF ReceptorInterleukin RelatedIFNARTumor Necrosis Factor ReceptorTNFRILInterferon-α/β receptorInterferon-alpha/beta receptorInhibitorinhibitorinhibit

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